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|
EFMC Short Course - Improving Compound Quality:
Physical Chemistry and DMPK Properties in Drug Discovery. Principles, Assays and Predictions |
| 22/03/2009 |
| 18:00 | Dinner |
|
| 23/03/2009 |
| 08:30 | Introduction to compound quality |
Dr. Han VAN DE WATERBEEMD
(, Saint Andre, France) |
| 10:00 | Coffee |
|
| 10:30 | Importance of physical chemical drug
properties: pKa, lipophilicity, solubility |
Dr Andy DAVIS
(ASTRAZENECA, Mölndal, Sweden) |
| 12:30 | Lunch |
|
| 13:30 | Measurement of physchem properties |
Dr. Barbara MASON
(PHYSCHEM CONSULTING, United Kingdom) |
| 15:00 | Tea |
|
| 15:30 | Basics of QSAR modeling |
Dr Andy DAVIS
(ASTRAZENECA, Mölndal, Sweden) |
| 19:30 | Dinner |
|
| 24/03/2009 |
| 08:30 | In silico ADMET |
Dr. Han VAN DE WATERBEEMD
(, Saint Andre, France) |
| 10:00 | Coffee |
|
| 10:30 | Estimation of oral absorption and bioavailability |
Dr. Han VAN DE WATERBEEMD
(, Saint Andre, France) |
| 12:00 | Lunch |
|
| 13:30 | Importance of adequate
pharmacokinetics: F, A, Vd, CL, t1/2, ppb |
Dr Don WALKER
(PFIZER, Sandwich, United Kingdom) |
| 15:00 | Tea |
|
| 15:30 | DMPK assays and their interpretation
for drug design teams |
Dr Don WALKER
(PFIZER, Sandwich, United Kingdom) |
| 19:30 | Dinner |
|
| 25/03/2009 |
| 08:30 | Prediction of drug metabolism |
Prof. Bernard TESTA
(UNIVERSITY HOSPITAL CENTRE, Lausanne, Switzerland) |
| 10:00 | Coffee |
|
| 10:30 | Role of drug metabolism and transporters
in drug design: assays, technologies,
interpretation |
Dr. Chris KOHL
(ACTELION, Allschwill, Switzerland) |
| 12:00 | Basic knowledge on drug metabolism
(reactions, enzymes), reactive metabolites, factors affecting drug metabolism, mDDI, prodrug design |
Prof. Bernard TESTA
(UNIVERSITY HOSPITAL CENTRE, Lausanne, Switzerland) |
| 13:00 | Lunch |
|
| 14:00 | Course end |
|
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