Discovery of Potent and Selective Smoothened Inhibitors for the Treatment of Hedgehog-dependent Tumors
Dr Stefan PEUKERT (NOVARTIS, Cambridge MA, United States)
12:15
Gut-Targeted Microsomal Triglyceride Transfer Protein Inhibitors to Treat Obesity: Design, Clinical Proof of Concept and Novel Chemical Leads
Dr Lieven MEERPOEL (JANSSEN R&D, Beerse, Belgium)
13:00
Lunch and Poster Session
Session 2: From Screening to Development
Session Chair
Prof. Pierre-Alain CARRUPT (UNIVERSITÉ DE GENÈVE, Geneva 4, Switzerland)
14:30
Discovery and Optimization of Kinase Inhibitors: Some Case Studies from GKS3β and IGF1R Inhibitors
Dr Dominique LESUISSE (SANOFI AVENTIS, Chilly-Mazarin, France)
15:15
Discovery and Lead Optimisation of a Novel Series of Highly Potent, Selective and Orally Bioavailable SYK Inhibitors
Dr Neil GARTON (GLAXOSMITHKLINE, Stevenage, United Kingdom)
16:00
Coffee Break and Poster Session
Session Chair
Dr Luc VAN HIJFTE (JANSSEN RESEARCH & DEVELOPMENT, Illkirch, France)
16:30
The Design, SAR and Synthesis of Novel ADAM-TS4 (Aggrecanase-1) Inhibitors for the Treatment of Osteoarthritis
Dr Chris DE SAVI (ASTRAZENECA R&D, Boston, United States)
17:15
Ehrlich Lecture - Title to be announced
Prof. Jean MARTINEZ (UNIVERSITY OF MONTPELLIER, Montpellier, France)
18:00
Final Announcements
18:30
Welcome drink sponsored by BIOalternatives
07/07/2011
Session 3: Other Innovative Approaches
Session Chair
Prof. Jens HASSERODT (ENS, Lyon, France)
09:00
Tumor Targeting Using Shiga Toxin: Syntheses and Biological Evaluations of Some Conjugates
Dr Frédéric SCHMIDT (INSTITUT CURIE, Paris, France)
09:45
Folding Oligomers with Predictable Structures and Properties
Dr Ivan HUC (IECB & CNRS - UNIVERSITÉ DE BORDEAUX, Bordeaux, France)
10:30
Coffee Break and Poster Session
Session 3: Other Innovative Approaches (Fol.)
Session 4: In Silico Approaches
Session Chair
Dr Pascal GEORGE (SCT & INDEPENDENT SCIENTIFIC EXPERT & ADVISER, Longvilliers, France)
11:00
Fragment-based Engineering of Protein-ligand Interactions Using NMR and Other Biophysical Methods : Towards Tailor-made Drugs
Prof. Jean-Marc LANCELIN (CPE, VILLEURBANNE Cedex, France)
11:45
Template Assembled Functional Biomolecules : Chemistry, Characterization and Validation as a Paradigm for Tailor Made Molecular Medicine
Prof. Pascal DUMY (ECOLE NATIONALE SUPÉRIEURE DE CHIMIE DE MONTPELLIER (ENSCM), Montpellier, France)
Session Chair
Dr Solo GOLDSTEIN (INSTITUT DE RECHERCHES SERVIER, Suresnes, France)
11:00
How can Computers Support Drug Discovery? In Silico Approaches for Anticipating Bioactivity Spectra, Analysing Adverse Drug Reactions and Predicting Ligand Activity Against Particular Protein Mutants
Prof. Andreas BENDER (UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom)
11:45
A Journey in Data and Chemical Spaces: Application to Pharmaceutical Sciences
Dr Philippe VAYER (LABORATOIRE SERVIER, Orléans, France)
12:30
Lunch and Poster Session
Session 5: Hit to Lead
Session 6: Fluorine in Medicinal Chemistry
Session Chair
Dr Olivier LAVERGNE (., Les Ulis, France)
14:00
The Mitotic Kinesin Eg5 as a Target for Drug Development in Cancer Chemotherapy: from Inhibitor Screening to in vivo Models
Prof. Frank KOZIELSKI (BEATSON INSTITUTE FOR CANCER RESEARCH, Glasgow, United Kingdom)
14:45
Proteomic Studies as a Guide in the Development of New Cyclin-dependent Kinase Inhibitors
Prof. Hervé GALONS (SCT & PARIS DESCARTES UNIVERSITY, Paris, France)
Session Chair
Dr Frédéric DOLLE (CEA, SERVICE HOSPITALIER FRÉDÉRIC JOLIOT, Orsay, France)
14:00
A Brief Guide to Fluorine-Protein Interactions for the Medicinal Chemist
Dr Jérôme AMAUDRUT (ABBOTT-LABORATOIRE FOURNIER, Daix, France)
14:45
Difluoromethylbenzoxazole (DFMB)Pyrimidine Thioether Derivatives: A Novel Class of Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors
Dr Maurice MEDEBIELLE (UNIVERSITÉ CLAUDE BERNARD LYON 1, Villeurbanne, France)
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