ASMC'11 St. Petersburg
21/08/2011
Tour 1: Pavlovsk and Pushkin
09:00-16:00
Tour 2: Petergof
10:00-17:00
Tour 3: Hermitage
14:00-18:00
14:00Registration
Tour 4: Boat Trips (Canals)
15:00-18:00
19:30Welcome Reception
22/08/2011
Session Chair
Dr Anthony WOOD
(PFIZER, Cambridge, United States)
08:30Opening
09:00Maitotoxin. An Inspiration for Synthesis
Prof. K.C. NICOLAOU
(THE SCRIPPS RESEARCH INSTITUTE & UNIVERSITY OF CALIFORNIA, Houston, United States)
09:50Tofacitinib (CP-690,550): Discovery of a Potent and Selective JAK Inhibitor
Dr Mark FLANAGAN
(PFIZER, Connecticut, United States)
10:30Coffee Break and Exhibition
11:00A few of my Favorite Rings: Catalysis Inspired by Lactones and Lactams
Prof. Vy M. DONG
(UNIVERSITY OF TORONTO, Toronto, Canada)
11:50Small Molecules Inhibitors of the WNT Signalling Pathway with Potential Applications in Oncology
Dr Alessandro PADOVA
(SIENA BIOTECH, Siena, Italy)
12:30Lunch and Exhibition
Session Chair
Dr Nikolai KUZNETSOV
(INEOS RAS, Moscow, Russia)
14:00Drug Discovery by Programmed Self-Assembly
Prof. Nicolas WINSSINGER
(UNIVERSITY OF STRASBOURG, Geneva, Switzerland)
14:50The Many Uses of Noncovalent Mass Spectrometry in Early-stage Drug Discovery
Dr Jean-Paul RENAUD
(NOVALIX, Ostwald, France)
15:30Small Molecule Inhibitors of the Neuropilin-1 VEGF-A Interaction
Dr Philip FALLON
(DOMAINEX, Saffron Walden, United Kingdom)
15:45Lead identification of a new class of P2Y12 inhibitors "From a low active and insoluble HTS hit to soluble and active lead compounds"
Mr Fredrik ZETTERBERG
(ASTRAZENECA, Gothenburg, Sweden)
16:00Coffee Break, Exhibition and Posters
16:30GPR119: Knowledge Based Lead Identification
Dr Sherrie L. PIETRANICO-COLE
(ROCHE, NUTLEY NJ, United States)
17:10Regioselective Reactions on a Chiral Substrate Controlled by the Configuration of a Chiral Catalyst
Prof. Henri KAGAN
(UNIVERSITY PARIS-SUD 11, ORSAY Cedex, France)
18:00Closing of the Day
18:30City Tour for Participants
23/08/2011
Session Chair
Dr Christophe GENICOT
(UCB SA, Braine-l'Alleud, Belgium)
08:30Synthesis of Marine Polyketides as Promising Anticancer Agents
Prof. Ian PATERSON
(CAMBRIDGE UNIVERSITY, Cambridge, United Kingdom)
09:20Chemical Probes for Epigenetics
Dr Mark BUNNAGE
(PFIZER, Boston, United States)
10:00The Chemical Biology Consortium- and Experimental Therapeutics Program
Dr Sanjay MALHOTRA
(NATIONAL CANCER INSTITUTE, Frederick, United States)
10:15Coffee Break, Exhibition and Posters
10:45Design Strategy for Preparation of Drug-like Polyheterocycles with Privileged Substructures for Discovery of Specific Small Molecule Modulators
Prof. Seung Bum PARK
(SEOUL NATIONAL UNIVERSITY, Seoul, Korea, South)
11:35Bromodomains a New Class of Epigenetic Targets Ripe for Small Molecule Drug Discovery
Dr Jason WITHERINGTON
(GLAXOSMITHKLINE R&D, Stevenage, United Kingdom)
12:15Identification of Leads from the Tres Cantos Antimalarial Set: Cyclopropyl Carboxamides Show Good Oral Bioavailability and Efficacy In Malarial Animal Models
Mrs Maria Lourdes RUEDA-BENEDE
(GLAXOSMITHKLINE, Tres Cantos, Spain)
12:30Lunch and Exhibition
13:15Poster Session 1
Session Chair
Prof. Gerhard ECKER
(UNIVERSITY OF VIENNA, Vienna, Austria)
14:15Minor Enantiomer Recycling – A Strategy for Improving Enantioselectivity
Prof. Christina MOBERG
(KTH SCHOOL OF CHEMICAL SCIENCE AND ENGINEERING, Stockholm, Sweden)
15:05Antibody Directed Cytotoxics
Prof. John FLYGARE
(GENENTECH, California, United States)
15:45Exploring the Rigid Mono- and Diamine Chemical Space
Dr Dmytro VOLOCHNYUK
(ENAMINE LTD., Kiev, Ukraine)
16:00Highly Efficient Catalytic System for C-H Activation: A Novel and Practical Synthesis of Angiotensin II Receptor Blockers
Dr Masahiko SEKI
(MITSUBISHI TANABE PHARMA CORPORATION, Fukuoka, Japan)
16:15Coffee Break, Exhibition and Posters
16:45Bicyclic Peptides with Tailored Binding Specificities for Therapeutic Application
Prof. Christian HEINIS
(ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL), Lausanne, Switzerland)
17:05Adventures in Medicinal Chemistry and Knowledge Capture
Dr Alexander MAYWEG
(F. HOFFMANN-LA ROCHE LTD, BASEL, Switzerland)
17:25Target Synthesis Directed Methodology Development
Prof. Dawei MA
(SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, Shanghai, China)
18:15Closing of the Day
24/08/2011
Session Chair
Dr Edmond DIFFERDING
(DIFFERDING CONSULTING, Louvain-la-Neuve, Belgium)
08:30From Homer to Hedgehog: Chemistry, Biological Investigations and Medical Perspectives of Cyclopamine
Prof. Athanassios GIANNIS
(UNIVERSITY OF LEIPZIG, Leipzig, Germany)
09:20Biochemical Efficiency, a Metrics for an Optimal Molecular Mechanism of Action
Dr David SWINNEY
(IRND3, Mountain View, United States)
10:00Identification of Bisaryloxy Azetidine Urea Derivatives as Fatty Acid Amide Hydrolase Inhibitors
Dr Hans MEISSNER
(VERNALIS, Winnersh, United Kingdom)
10:15Coffee Break, Exhibition and Posters
10:45Lessons in Chemoselectivity: Total Synthesis of Polyphenolic Natural Products
Prof. Scott SNYDER
(COLUMBIA UNIVERSITY, New York, United States)
11:35The Resurgence of Covalent Drugs
Dr Juswinder SINGH
(AVILA THERAPEUTICS, United States)
12:15Halogen Bonding in Protein–ligand Interactions
Mr Leo HARDEGGER
(ETH ZURICH, Zürich, Switzerland)
12:30Lunch and Exhibition
13:15Poster Session 2
Free Afternoon
Tour 5: Hermitage
14:30-18:30
Tour 6: Canals
15:00-18:00
25/08/2011
Session Chair
Prof. Nicolas WINSSINGER
(UNIVERSITY OF STRASBOURG, Geneva, Switzerland)
08:30Validation of N-Myristoyltransferase as a Drug Target
Prof. Paul WYATT
(UNIVERSITY OF DUNDEE, Dundee, United Kingdom)
09:20Novel Metabotropic Glutamate Receptor 4 (mGluR4) Allosteric Potentiators for the Treatment of Parkinsons’s Disease
Dr Sylvain CELANIRE
(ADDEX PHARMACEUTICALS, Geneva, Switzerland)
10:00The Chemistry of Targeting Protein-Protein Interactions: Thinking Outdside of the Box
Dr Giovanna ZINZALLA
(LONDON SCHOOL OF PHARMACY, London, United Kingdom)
10:15Coffee Break, Exhibition and Posters
10:45Asymmetric Synthesis of Bioactive Molecules
Prof. Mikiko SODEOKA
(RIKEN, Hirosawa, Japan)
11:35A Step Closer to Hepatitis C Remedy: TMC435, an HCV Protease Inhibitor in Advanced Clinical Trial
Dr Pierre RABOISSON
(JANSSEN PHARMACEUTICAL COMPANIES, Beerse, Belgium)
12:15The Grandisine Alkaloids as Selective δ-Opioid Receptor Agonists; When is a Natural Product not a Natural Product?
Prof. Richard TAYLOR
(UNIVERSITY OF YORK, York, United Kingdom)
12:45Lunch and Exhibition
Session Chair
Prof. K.C. NICOLAOU
(THE SCRIPPS RESEARCH INSTITUTE & UNIVERSITY OF CALIFORNIA, Houston, United States)
14:00Discovery and Development of Novel Antimalarials
Dr Rodney KIP GUY
(ST. JUDE CHILDREN'S RESEARCH HOSPITAL, Memphis, United States)
14:50Accelerated C-H Activation Reactions: Enantioselectivity and Positional Selectivity
Prof Jin-Quan YU
(THE SCRIPPS RESEARCH INSTITUTE, La Jolla, United States)
15:40Coffee Break and Exhibition
16:10Metal-Catalyzed C–H Bond Functionalizations for Sustainable Synthesis
Prof. Lutz ACKERMANN
(GEORG-AUGUST UNIVERSITY GOETTINGEN, Goettingen, Germany)
17:00Magical Power of d-Block Transition Metals—Pd-Catalyzed Cross-Coupling and Zr-Catalyzed Asymmetric carboalumination of Alkenes (ZACA)
Prof. Ei-ichi NEGISHI
(PURDUE UNIVERSITY, West Lafayette, United States)
17:50Closing Remarks
19:00Symposium Banquet
26/08/2011
Tour 7: Pavlovsk-Pushki
09:00-18:00
Tour 8: Petergof
10:00-17:00
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