5th EFMC Short Course on Medicinal Chemistry - Spring 2012
01/04/2012
18:00
Dinner
Introduction to Course
19:30
Drug Discovery in the Century of Systems and Chemical Biology
Dr Brian HARMS (MERRIMACK PHARMACEUTICALS, Cambridge, MA, United States) Dr Thomas KLABUNDE (SANOFI-AVENTIS, Frankfurt am Main, Germany)
20:30
Close
02/04/2012
07:30
Breakfast
Session I: Understanding Disease Physiology
08:30
Modelling of Physiological Processes to Understand Disease
Dr Brian HARMS (MERRIMACK PHARMACEUTICALS, Cambridge, MA, United States) Dr Thomas KLABUNDE (SANOFI-AVENTIS, Frankfurt am Main, Germany)
09:00
Lost in Translation (?)
Dr Henning SCHMIDT (NOVARTIS PHARMA AG, Basel, Switzerland)
09:45
Optimizing Lead Compound Selection Using Mechanistic Physiological Modeling
Dr Christina FRIEDRICH (ROSA & CO, San Carlos, United States)
10:30
Coffee Break
10:45
Physiological and Disease Modelling for Diabetes: Glucose/insulin Homeostasis
Dr Thomas KLABUNDE (SANOFI-AVENTIS, Frankfurt am Main, Germany)
11:00
Qualifying Mechanistic Physiological Models for Use in Pharmaceutical Discovery and Development, Part I
Dr Christina FRIEDRICH (ROSA & CO, San Carlos, United States)
WORKSHOP/TUTORIAL
13:00
Lunch
14:00
Qualifying Mechanistic Physiological Models for Use in Pharmaceutical Discovery and Development, Part II
Dr Christina FRIEDRICH (ROSA & CO, San Carlos, United States)
15:30
Coffee Break
Session II: Understanding Complex Biological Systems
16:00
Modelling of Cellular Systems: Helping you to Identify the Most Relevant Switches
Dr Brian HARMS (MERRIMACK PHARMACEUTICALS, Cambridge, MA, United States) Dr Thomas KLABUNDE (SANOFI-AVENTIS, Frankfurt am Main, Germany) Dr Julio SAEZ-RODRIGUEZ (EMBL-EBI, Cambridge, United Kingdom)
16:45
Comparative Logical Models of Signalling Networks in Normal and Transformed Hepatocytes
Dr Julio SAEZ-RODRIGUEZ (EMBL-EBI, Cambridge, United Kingdom)
17:30
End day-1, followed by a social event
03/04/2012
07:30
Breakfast
09:00
Modelling of EGFR Signalling for Target Identification
Dr Brian HARMS (MERRIMACK PHARMACEUTICALS, Cambridge, MA, United States)
09:45
The Virtual Pancreatic Beta-cell: a Mod & Sim Approach in Diabetes Drug Discovery
Dr Thomas KLABUNDE (SANOFI-AVENTIS, Frankfurt am Main, Germany)
10:30
Coffee Break
WORKSHOP/TUTORIAL
11:00
Models of Signalling Networks: from Coarse Boolean Approaches to Dynamic Models of Underlying Biochemistry
Dr Julio SAEZ-RODRIGUEZ (EMBL-EBI, Cambridge, United Kingdom)
13:00
Lunch
Session III: Target Identification by Chemical Biology
14:00
Chemical and Systems Biology Approaches for Target Identification
Dr Uwe RIX (H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, Tampa, FL, United States)
14:45
Targets and Molecular Mechanisms: Charting Kinase Inhibitors in Malignant Diseases Using Chemical Proteomics
Dr Uwe RIX (H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, Tampa, FL, United States)
15:30
Coffee Break
WORKSHOP/TUTORIAL
16:00
Computational Approaches to Target Prediction
Dr Thomas KLABUNDE (SANOFI-AVENTIS, Frankfurt am Main, Germany)
17:00
End day-2
04/04/2012
07:30
Breakfast
Session IV: Understand Disease Mechanisms from Transcriptomics Data and Map Disease and Drug-response Signatures
09:00
Review Tools and Case Studies for Computational Drug Repositioning
Dr Francesco IORIO (EMBL-EBI & WELLCOME TRUST SANGER INSTITUTE, Cambridge, United Kingdom)
09:45
Review Computational Methods and Case Studies for Understanding Disease Mechanisms and Drug Responses
Dr Francesco IORIO (EMBL-EBI & WELLCOME TRUST SANGER INSTITUTE, Cambridge, United Kingdom)
10:30
Coffee Break
WORKSHOP/TUTORIAL
11:00
Using cMap and MANTRA to identify Drug Repositioning Opportunities
Dr Francesco IORIO (EMBL-EBI & WELLCOME TRUST SANGER INSTITUTE, Cambridge, United Kingdom)
