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MedChem 2012 - From Rapid Dissociation to Irreversible Inhibition Optimisation of Drug-Target Residence Time |
30/11/2012 |
08:00 | Registration |
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08:50 | Opening |
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09:00 | Looking Beyond Potency: Importance of Assessing Residence Time in Chemistry and Its Impact on Drug Discovery |
Dr Yogesh SABNIS (UCB PHARMA, Braine-l'Alleud, Belgium) |
09:50 | Kinetics in Drug Discovery. A case for G Protein-Coupled Receptors |
Prof. Ad P. IJZERMAN (UNIVERSITY OF LEIDEN, Leiden, The Netherlands) |
10:40 | Coffee Break |
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11:15 | Kinetics Based Early Drug Screening : a New Application for DNA-Encoded Chemical Libraries |
Dr Peter BLAKSKJÆR (VIPERGEN, Copenhagen, Denmark) |
11:35 | A ‘Fast’ Track to Atypicality – The Discovery of JNJ37822681 for the Treatment of Schizophrenia |
Dr Gregor J. MACDONALD (JANSSEN RESEARCH & DEVELOPMENT, Beerse, Belgium) |
12:25 | Sandwich Lunch |
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14:00 | Kinetic Screening in Drug Discovery |
Prof. Andrew HOPKINS (UNIVERSITY OF DUNDEE, Dundee, United Kingdom) |
14:50 | How to Design Better Small Molecule Ligands: a Case of CCR2 Antagonists |
Mr Maris VILUMS (LEIDEN UNIVERSITY, Leiden, The Netherlands) |
15:10 | A Computational Approach to Predict Inhibitor Binding Kinetics : the PNP Case |
Dr Walter ROCCHIA (FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, Genova, Italy) |
15:30 | Coffee Break and Poster Session |
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16:05 | The Resurgence of Covalent Inhibitors |
Dr Russell PETTER (CELGENE AVILOMICS RESEARCH, Bedford, United States) |
16:55 | Irreversible Inhibitors of Serine Proteases: Tools or Drugs? |
Prof. Koen AUGUSTYNS (UNIVERSITY OF ANTWERP, Antwerp, Belgium) |
17:45 | Closing Remarks |
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