SDA 2010
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Single Domain Antibodies Come of Age
14/10/2010
08:30Registration, poster set-up and welcome coffee
09:15Conference Opening and Welcome Address
Prof. Serge MUYLDERMANS (VUB-VIB, Brussels, Belgium) - Cellular and Molecular Immunology, Department of Molecular and Cellular Interactions
Dr Hilde REVETS (ABLYNX, Antwerpen , Belgium)
09:30Welcome Address
Dr Edwin MOSES
(CEO, ABLYNX, Ghent, Belgium)
Session 1: The Rise of Single-Domain Antibodies
Session Chair
Prof Martin FLAJNIK
(UNIVERSITY OF MARYLAND, Baltimore, United States)
09:35Keynote Address: Raymond Hamers
Prof. Serge MUYLDERMANS (VUB-VIB, Brussels, Belgium) - Cellular and Molecular Immunology, Department of Molecular and Cellular Interactions
Dr Hilde REVETS (ABLYNX, Antwerpen , Belgium)
10:00From Whole Monoclonal Antibodies to Single Domain Antibodies: Think small
Dr Jean-Luc TEILLAUD
(CENTRE DE RECHERCHE DES CORDELIERS UNIVERSITÉ PIERRE ET MARIE CURIE PARIS 6, Paris, France)
10:30Discovery of Camelid Heavy-chain Only Antibodies and Generation of Nanobodies
Prof. Serge MUYLDERMANS
(VUB-VIB, Brussels, Belgium) - Cellular and Molecular Immunology, Department of Molecular and Cellular Interactions
11:00Coffee Break and Poster Viewing
11:20Overview of Ig-NARs and Generation of V-NARs
Prof Martin FLAJNIK
(UNIVERSITY OF MARYLAND, Baltimore, United States)
Session 2: Crossing the Barriers: BBB and Membranes, Intracellular Targeting
Session Chair
Dr Danica STANIMIROVIC
(INSTITUTE FOR BIOLOGICAL SCIENCES, Ottawa, Ontario, Canada)
11:50Single Domain Antibodies Targeting the BBB and the Brain Vasculature
Dr Danica STANIMIROVIC
(INSTITUTE FOR BIOLOGICAL SCIENCES, Ottawa, Ontario, Canada)
12:20Cell Penetrating Anti-GFAP VHH Spontaneously Cross the BBB and Specifically Recognizes Astrocytes
Dr Pierre LAFAYE
(INSTITUT PASTEUR PARIS, Paris, France)
12:50Networking Lunch and Poster Viewing
14:00A Nanobody targeting the N-terminal alpha-helical Multimerization Domain of HIV-1 Rev prevents Viral Production
Dr Dirk DAELEMANS
(REGA INSTITUTE FOR MEDICAL RESEARCH, Leuven, Belgium)
14:30A Novel and Unique Method to introduce Nanobodies Inside a Cell
Dr Luis Angel FERNÁNDEZ-HERRERO
(CENTRO NACIONAL DE BIOTECNOLOGIA, Madrid, Spain)
Session 3: Alternative Delivery of Single Domain Antibodies
Session Chair
Dr Daniel CHRIST
(GARVAN INSTITUTE OF MEDICAL RESEARCH, Sydney, Australia)
15:00Lactobodies: Lactobacilli Expressing Variable Domain of Llama Heavy-chain Antibody Fragments (Lactobodies) Confer Protection against Rotavirus-induced Diarrhea.
Prof. Lennart HAMMARSTRÖM
(KAROLINSKA INSTITUTE, Stockholm, Sweden)
15:30Engineering of Aggregation-resistant Human Antibody Domains by Phage Display
Dr Daniel CHRIST
(GARVAN INSTITUTE OF MEDICAL RESEARCH, Sydney, Australia)
16:00Pulmonary Delivered Domain Antibodies: anti-TNFR1 dAb for Lung Diseases
Dr Peter MORLEY
(GLAXOSMITHKLINE, Stevenage, United Kingdom)
16:30Coffee Break and Poster Viewing
Session 4: Selected Abstracts for Oral Presentation
Session Chair
Prof. Serge MUYLDERMANS
(VUB-VIB, Brussels, Belgium) - Cellular and Molecular Immunology, Department of Molecular and Cellular Interactions
16:50OC 1 - Inhibition of Actin Filament Capping by a CapG SDA restrains Cellular Migration and Invasion
Dr katrien VAN IMPE
(UGENT, Gent, Belgium)
17:10OC2 - Development of SDA against the HIV-1 ENV Glycoprotein to inhibit Infection of CD4+ Cells
Ms Julie MATZ
(INSERM, marseille, France)
17:30OC 3 - ART-2 Blocking Nanobodies Protect Regulatory T Cells from NAD-induced Cell Death
Mr Björn RISSIEK
(UNIVERSITY MEDICAL CENTER HAMBURG-EPPENDORF, Hamburg, Germany)
17:50OC 4 - Analysis of BBB Permeablity for Nanobodies using Microdialysis
Dr Ralph CLINCKERS
(VUB, Jette - Brussel, Belgium)
18:10Closing Remarks from Co-Chairs
18:20Networking Drink with Lite Bites
15/10/2010
Session 5: Engineering Single Domain Antibodies for Improved Function
Session Chair
Prof. Guus VAN DONGEN
(VU AMSTERDAM, Amsterdam, The Netherlands)
09:00Improved Tumor Targeting of Anti-EGFR Nanobodies through Albumin Binding
Prof. Guus VAN DONGEN
(VU AMSTERDAM, Amsterdam, The Netherlands)
09:30Engineering Nanobodies for Improved Treatment of Infectious Diseases
Dr Michiel HARMSEN
(CENTRAL VETERINARY INSTITUTE OF WAGENINGEN, Lelystad, The Netherlands)
10:00Using dAbs to Control in Vivo Exposure of Metabolic Peptides
Dr Laurent JESPERS
(GSK, Cambridge, United Kingdom)
Session 6: Targeting Less Accessible Antigens Including Certain Membrane-associated Proteins, Enzymes, Ion Channels and G-protein Coupled Receptors that weave in and out Cell Surfaces
Session Chair
Dr Friedrich KOCH-NOLTE
(INSTITUTE OF IMMUNOLOGY, UNIVERSITY MEDICAL CENTER HAMBURG-EPPENDORF, Hamburg, Germany)
10:30Inhibitory and Stimulatory Nanobodies Against a Nucleotide-gated Ion Channel
Dr Friedrich KOCH-NOLTE
(INSTITUTE OF IMMUNOLOGY, UNIVERSITY MEDICAL CENTER HAMBURG-EPPENDORF, Hamburg, Germany)
11:00Coffee Break and Poster Viewing
11:20CXCR4-specific Nanobodies Selectively and Potently Inhibit Chemotaxis and HIV Entry
Prof. Martine SMIT
(VU AMSTERDAM, Amsterdam, The Netherlands)
11:50'Engineering Nanobodies that Bind to Human Lysozyme and Inhibit its Conversion to Amyloid Fibrils: Prospects in Systemic and Neurodegenerative Protein Aggregation Diseases
Dr Mireille DUMOULIN
(UNIVERSITY OF LIÈGE, Liège, Belgium) - Laboratory of Enzymology and Protein Folding, Centre for Protein Engineering
12:20Llama Single Domain Antibodies as Rugged Countermeasures for Filoviruses and BoNT
Dr Andrew HAYHURST
(SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH, San Antonio, United States)
12:50Networking Lunch and Poster Viewing
13:30Nanobodies with G protein like properties stabilize a G Protein-Coupled Receptor Active State
Prof. Jan STEYAERT
(VUB-VIB, Brussels, Belgium) - Structural Biology, Department of Molecular and Cellular Interactions
Session 7: Imaging Applications of Single Domain Antibodies
Session Chair
Dr Hilde REVETS
(ABLYNX, Antwerpen , Belgium)
14:00Connecting Biochemistry and Cell Biology with Nanobodies
Dr Tina ROMER
(LMU MÜNCHEN, Martinsried, Germany)
14:30Molecular Imaging using Nanobodies
Dr Tony LAHOUTTE
(VUB, Brussels, Belgium) - Laboratory for in vivo Cellular and Molecular Imaging, Nuclear Medicine Department
Session 8: Single Domain Antibodies in the Clinic
Session Chair
Dr Josi HOLZ
(CMO, ABLYNX, Ghent, Belgium)
15:00Considerations for the Manufacture of Nanobodies from Pipeline into the Clinic
Dr Ann BRIGÉ
(ABLYNX, Zwijnaarde, Belgium)
15:30Nanobodies: Roadmap to Clinical Proof of Concept. Review of Phase I Experience.
Dr Josi HOLZ
(CMO, ABLYNX, Ghent, Belgium)
16:00Closing Remarks from the Co-Chairs
16:15Presentation of the Young Scientist Awards & Closure of the Symposium
Dr Edwin MOSES
(CEO, ABLYNX, Ghent, Belgium)
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