| Sunday May 5, 2013 |
| 12:00 | Registration |
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| 14:00 | Pre-symposium Excursions (optional, and subject to registration) |
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| 19:30 | Welcome Reception |
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| Monday May 6, 2013 |
| 08:30 | Opening Ceremony |
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| Session Chair |
Prof. Dr Peter H. SEEBERGER
(MAX PLANCK INSTITUTE OF COLLOIDS AND INTERFACES, Berlin, Germany) |
| 08:50 | Targeting Protein Surfaces Using Designed Proteomimetics |
Prof. Andrew HAMILTON
(UNIVERSITY OF OXFORD, Oxford, United Kingdom) |
| 09:40 | Design and Optimization of Pyrazinecarboxamide-Based Inhibitors of Diacylglycerol Acyltransferase 1 (DGAT1) Leading to the Clinical Candidate AZD7687 |
Dr Petra JOHANNESSON
(ASTRAZENECA, Mölndal, Sweden) |
| 10:20 | New Inhibitors of the Enzyme Isoprenylcysteine Carboxyl Methyltransferase (ICMT) |
Prof. María del Mar MARTÍN-FONTECHA
(COMPLUTENSE UNIVERSITY OF MADRID, Madrid, Spain) |
| 10:35 | Coffee break and Exhibition |
|
| 11:05 | Oligonucleotide Synthesis Interfaced with Molecular Biology and Nanotechnology |
Prof. Marvin CARUTHERS
(UNIVERSITY OF COLORADO, Boulder, United States) |
| 11:55 | BETting on Epigenetic Targets : From Phenotypic Discovery to First Time in Man |
Dr Chun-wa CHUNG
(GLAXOSMITHKLINE, Stevenage, United Kingdom) |
| 12:35 | Virtual Screening and Design of New Pharmaceutical Agents Using PASS Approach |
Prof. Vladimir POROIKOV
(INSTITUTE OF BIOMEDICAL CHEMISTRY, Moscow, Russia) |
| 12:50 | Lunch and Exhibition |
|
| Session Chair |
Dr Laurent PROVINS
(UCB, Braine-l'Alleud, Belgium) |
| 14:00 | Synthetic Organic Photochemistry in Batch and Flow |
Prof. Kevin BOOKER-MILBURN
(UNIVERSITY OF BRISTOL, Bristol, United Kingdom) |
| 14:50 | The Discovery of the Macrocyclic HCV NS3/4A Protease Inhibitor MK-5172 |
Dr Michael ROWLEY
(MERCK RESEARCH LABORATORIES, Kriens, Switzerland) |
| 15:30 | Novel Synthetic Chemical Chaperones as a New Basis For Amyotrophic Lateral Sclerosis (ALS) Treatment |
Dr Arie-Lev GRUZMAN
(BAR ILAN UNIVERSITY, Ramat Gan, Israel) |
| 15:45 | Discovery of Highly Potent S1P1 Receptor Antagonists with in vivo Efficacy |
Dr Jean QUANCARD
(NOVARTIS PHARMA, Basel, Switzerland) |
| 16:00 | Coffee break and Exhibition |
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| 16:30 | A New Approach to Tuberculosis Research: The Lilly TB Drug Discovery Initiative |
Dr Philip A. HIPSKIND
(ELI LILLY & COMPANY, Indianapolis, United States) |
| 17:10 | Making Molecular Prosthetics via Iterative Cross-Coupling with MIDA Boronates |
Prof. Martin D. BURKE
(UNIVERSITY OF ILLINOIS, Urbana, United States) |
| 18:00 | Closing of the day |
|
| 21:00 | Moscow by Night Tour (free of charge, but subject to registration) |
|
| Tuesday May 7, 2013 |
| Session Chair |
Prof. Hans Ulrich STILZ
(NOVO NORDISK, Malov, Denmark) |
| 08:30 | Versatile Synthetic Methods: Access to Bioactive Molecules |
Prof. Janine COSSY
(ESPCI PARISTECH, Paris, France) |
| 09:20 | EFMC Prize for a Young Medicinal Chemist in Academia
Chemical Approaches to Biology and Therapeutics |
Dr Gonçalo BERNARDES
(INSTITUTO DE MEDICINA MOLECULAR, LISBON, PORTUGAL & UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom) |
| 09:40 | EFMC Prize for a Young Medicinal Chemist in Industry
Free-Wilson and Structural Approaches to Co-Optimising Human and Rodent Isoform Potency for 11β-Hydroxysteroid Dehydrogenase Type 1 (11β -HSD1) Inhibitors |
Dr Frederick GOLDBERG
(ASTRAZENECA, Macclesfield, United Kingdom) |
| 10:00 | Rapid Kinase SAR Generation: an Integrated Approach to Synthesis, Screening and Molecular Design |
Dr David PARRY
(CYCLOFLUIDIC LTD, Welwyn Garden City Herts, United Kingdom) |
| 10:15 | Coffee break and Exhibition |
|
| 10:45 | Highly Anti-inflammatory Dendritic Polyglycerol Sulfates - a Multiple Target Approach |
Prof. Rainer HAAG
(FREE UNIVERSITY BERLIN, Berlin, Germany) |
| 11:35 | Peptide Chemologics |
Dr Lee ROBERTS
(PFIZER, Sandwich, United Kingdom) |
| 12:15 | Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors |
Dr Graeme SMITH
(VERTEX PHARMACEUTICALS, Cambridge, United States) |
| 12:30 | Lunch and Exhibition |
|
| 13:30 | Poster Session 1 |
|
| Session Chair |
Dr Edmond DIFFERDING
(DIFFERDING CONSULTING, Louvain-la-Neuve, Belgium) |
| 14:30 | Organic Molecules as Biological Probes...an exciting journey |
Prof. Cristina NEVADO
(UNIVERSITY OF ZURICH, Zurich, Switzerland) |
| 15:20 | Discovery and Initial Clinical Results of [18F]-UCB-H, First PET Radiotracer Targeting Synaptic Vesicle 2A |
Dr Anne VALADE
(UCB, Braine-l'Alleud, Belgium) |
| 16:00 | Self-Immolative Spacers in Prodrug/Profluorophore Strategies: Determination of Kinetic Parameters for Release of Single or Multiple Substrates. |
Dr Frédéric SCHMIDT
(INSTITUT CURIE, Paris, France) |
| 16:15 | Synthetic Approach to Novel Melatonin Receptor Ligands |
Mrs Maria VOLKOVA
(MOSCOW STATE UNIVERSITY, CHEMISTRY DEPARTMENT, Moscow, Russia) |
| 16:30 | Coffee break and Exhibition |
|
| 17:00 | The Design and Characterization of Targeted Covalent Inhibitors of Btk |
Dr Eric SCHWARTZ
(CELGENE AVILOMICS RESEARCH, Cambridge, United States) |
| 17:40 | P2X Receptors: ATP-Gated Ion Channels as Novel Drug Targets |
Prof. Christa MÜLLER
(UNIVERSITY OF BONN, Bonn, Germany) |
| 18:30 | Closing of the day |
|
| Wednesday May 8, 2013 |
| Session Chair |
Dr Rosa María RODRÍGUEZ SARMIENTO
(F. HOFFMANN-LA ROCHE, Basel, Switzerland) |
| 08:30 | Harnessing Synergy Between Natural Products and Synthesis Towards Drug Discovery |
Prof. Goverdhan MEHTA
(UNIVERSITY OF HYDERABAD, Hyderabad, India) |
| 09:20 | Advances in Targeting Voltage-Gated Sodium Channels with Small Molecules |
Dr Antonio NARDI
(GRÜNENTHAL, Aachen, Germany) |
| 10:00 | Design, Synthesis and Application Of Fluorinated Amino Acids as Labels to Study the Membrane Active Peptides by Solid State 19F NMR |
Dr Pavel MYKHAILIUK
(ENAMINE LTD, Kyiv, Ukraine) |
| 10:15 | Coffee break and Exhibition |
|
| 10:45 | Engineering of Small Non-Antibody Protein Scaffolds as Novel Biopharmaceuticals: from Anticalins to PASylation |
Prof. Arne SKERRA
(TECHNICAL UNIVERSITY MUNICH, München, Germany) |
| 11:35 | Bitopertin (RG1678), a Potent and Selective Glycine Re-Uptake Inhibitor for the Treatment of Schizophrenia |
Dr Emmanuel PINARD
(F. HOFFMANN-LA ROCHE, Basel, Switzerland) |
| 12:15 | Fragment-Based Design of Inhibitors of The Antituberculotic Target 1-Deoxy-D-Xylulose-5-Phosphate Synthase Exploiting an Innovative Combination of NMR Techniques |
Mrs Tiziana MASINI
(UNIVERSITY OF GRONINGEN, Groningen, The Netherlands) |
| 12:30 | Lunch and Exhibition |
|
| 13:30 | Poster Session 2 |
|
| Session Chair |
Dr Alan D. PALKOWITZ
(ELI LILLY & CO., Indianapolis, United States) |
| 14:30 | New Strategies in Organic Synthesis: Recent Advances Based on Catalytic Reactions of Boron Reagents |
Prof. James P. MORKEN
(BOSTON COLLEGE, Chestnut Hill, United States) |
| 15:20 | Identification of a Novel Series of Orexin Receptor Antagonists with a Distinct Effect on Sleep Architecture |
Dr Simona COTESTA
(NOVARTIS, Basel, Switzerland) |
| 16:00 | Antibody Drug Conjugates for the Treatment of Cancer |
Dr Paul POLAKIS
(GENENTECH, San Francisco, United States) |
| 16:40 | Coffee break and Exhibition |
|
| 17:10 | Metal Catalyzed Arylation of Nucleophiles |
Dr Marc TAILLEFER
(ENSCM, Montpellier, France) |
| 18:00 | From Organic Synthesis to Biomedical Sciences - from Polyhydroxybutyrate (PHB) to Cell-Penetrating Peptides |
Prof. Dieter SEEBACH
(ETH ZURICH, Zürich, Switzerland) |
| 18:50 | Closing of the day |
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| 20:00 | Symposium Banquet (optional, and subject to registration) |
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| Thursday May 9, 2013 |
| 09:00 | Post-symposium Excursions (optional, and subject to registration) |
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