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Invited Speakers
Keynote Lecture
Industrial Preparative HPLC for Production of API Including Most Common Unit Operations; Membrane Operations, Evaporation, Crystallization
| Roman BURJA (LEK PHARMACEUTICALS D.D., Menges, Slovenia) Read more
Roman Burja is Head Technical Life Cycle Management and Manufacturing Science & Technology Site Head at Lek Pharmaceuticals d.d. at Menges Site. He finished study of Chemical engineering at University of Ljubljana in 2001. The same year he joined Lek as Process Engineer in Development and then assumed roles with increased responsibility. In 2003 he worked as Project Manager responsible for pHPLC process scale up and production of API. In 2007 he joined API Production as site leadership team member for the execution of product and technology transfers, validation of manufacturing processes and use of up to date technology. In his current role he works in the field of technology transfers, scale up and process optimization including pHPLC, synthesis, membrane operations and complex API crystallization. Close window
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Keynote Lecture
Continuous Processing by CCC/CPC: Where to Plug and How to Play When Everything is Fluid
| Svetlana IGNATOVA (BRUNEL UNIVERSITY, Uxbridge, United Kingdom) Read more
Dr Svetlana Ignatova is an Associate Professor at the Institute of Environment, Health and Societies and a Director of the Advanced Bioprocessing Centre at Brunel University, London. Her career has involved the application and development of Counter-current liquid-liquid extraction technology (often referred to as CCC). After she graduated from the Chemistry Department of Moscow State University (Russia) in 1993, she focussed on CCC theory and its application to inorganic and radioactive analysis culminating in her PhD, awarded in 2001 from Russian Academy of Sciences. After moving to Brunel University in 2003, Dr Ignatova worked closely with industry developing novel applications of CCC/CPC and its scale up. Her work on the recovery of actives from waste streams won a prize at SPICA 2012 in Brussels and she was recently invited to participate in a UK Government “Mission to China on Sustainable Manufacturing”. Close window
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Keynote Lecture
Multi-Column Chromatography: Challenges and Opportunities
| Yoshiaki KAWAJIRI (GEORGIA INSTITUTE OF TECHNOLOGY, Atlanta, United States) Read more
Dr. Yoshiaki Kawajiri is an assistant professor in the School of Chemical & Biomolecular Egnineering at Georgia Institute of Technology, USA. He earned his Master and Bachelor of Engineering degrees in chemical engineering from Kansai University in Osaka, Japan in 1997 and 1999, respectively. After working as an R&D engineer at Organo Corporation in Saitama, Japan for four years, he completed his Ph.D. in chemical engineering at Carnegie Mellon University in the U.S. in 2007. Then he carried out his postdoctoral study at the Max Planck Institute for Dynamics of Complex Technical Systems in Magdeburg, Germany, supported by an Alexander von Humboldt Research Fellowship. His research interests include modeling, optimization, and design of novel separation processes for chemical, pharmaceutical, and energy industries, such as simulated moving bed chromatography, crystallization, and adsorption process for carbon capture. Close window
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Keynote Lecture
Peptide Purification: State-of-the-Art and Challenges
| Thomas MEIER (BACHEM AG, Bubendorf, Switzerland) Read more
Thomas Meier is Vice President Manufacturing and member of the Executive Committee at Bachem AG, Bubendorf, Switzerland. He studied Chemistry at the Swiss Federal Institute in Zurich (ETHZ, Switzerland) and the Zurich University of Applied Science. He joined Bachem AG in 1993 as a peptide bench chemist. In 1997 he was promoted Director API. From then on, he led the API manufacturing department in Bachem, and was promoted Vice President Production in 2008. He was involved in numerous interdisciplinary teams developing, implementing and executing cGMP peptide API manufacturing processes, thus innovating large scale peptide manufacturing in a cGMP regulated environment. In addition he led the Solid-Phase Peptide Synthesis and Purification extension project that designed, installed and qualified large scale peptide synthesizer and preparative HPLC systems.
From 2001 till 2004 he was in charge of Peptide manufacturing at Peninsula Inc. in San Carlos, California.
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Keynote Lecture
Pharmaceutical Small Molecule Purification: Where Are We and Where Do We Need to Be?
| Larry MILLER (AMGEN, Cambridge, United States) Read more
Larry Miller is a Principal Scientist in the Discovery Analytical Sciences group at Amgen in Cambridge, MA. He graduated with a BS degree from the University of Illinois in Urbana-Champaign and a MS from Roosevelt University. He has over 30 years of experience performing small molecule achiral and chiral purifications at the mg to multi-kg scale/ During his career he spent 20 years at Searle/Pharmacia and has spent the last 10 years at Amgen At Amgen he is responsible for discovery and early development purification support utilizing preparative SFC and HPLC. Larry has over 30 peer reviewed publications and over 35 presentations at scientific meetings and serves as co-instructor for SFC short courses in the US and Europe. In addition Larry is the current president of the Green Chemistry Group which organizes the annual SFC conference. Close window
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Keynote Lecture
Chromatographer: What Could Modeling Do for You?
| Roger-Marc NICOUD (FOUNDER AND FORMER CEO NOVASEP, CONSULTANT, Lay-Saint-Christophe, France) Read more
Roger-Marc Nicoud got a PhD from University of Lorraine in process simulation for the nuclear industry. He joined Separex in 1987, first as a Technical Director and then as a Managing Director until 1995. Between 1993 and 1995, he also occupied a position of Professor and head of a research laboratory involved in thermodynamics at the University of Lorraine.
Roger-Marc Nicoud founded Novasep in 1995 with the vision to develop comprehensive solutions for the production of bio- and synthetic molecules. Novasep became a leader serving the life sciences industry with a recognized portfolio of innovative technologies. He held the position of CEO of Novasep until October 2012, and Chairman of the Novasep Supervisory Board until February 2014. Roger-Marc Nicoud is currently writing a book `Chromatographic processes: modelling, simulation and design` to be published early 2015 by Cambridge University Press .
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Keynote Lecture
Chromatography and Crystallization: Good Partners in Separating Enantiomers
| Andreas SEIDEL-MORGENSTERN (MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany) Read more
Prof. Seidel-Morgenstern graduated at Technische Hochschule Leuna-Merseburg in 1983 (Dipl.-Ing. in Chemcial Engineering) and received a Ph.D. in 1987 from the Institute of Physical Chemistry of the Academy of Sciences in Berlin. Between 1991 and 1992 he worked as a postdoctoral fellow at the University of Tennessee in Knoxville. In 1994 he finished the Habilitation at the Technical University in Berlin. He acquired industrial experience working for Schering AG in Berlin (1995) before becoming Professor of Chemical Process Engineering at the Otto von Guericke University in Magdeburg. In 2002 he was appointed as a Director at the Max Planck Institute for Dynamics of Complex Technical Systems in Magdeburg, where he leads the department “Physical and Chemical Foundations of Process Engineering”. His research fields are mainly reaction engineering, heterogeneous catalysis, preparative chromatography and crystallization based separation processes. Close window
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Oral Communications
Highly Active Small Molecules and Peptides: Intrinsic Reduction of Risks by the Use of Preparative Chromatography and Flow Technologies
| Ulf ALTENHOENER (LONZA AG, Aarau , Switzerland) Read more
Chemical Engineer, studied at University of Dortmund PhD-Thesis at University of Dortmund (determination of empirical parameters for the simulation of chromatographical seperation processes). From 1997 to 99 at Schering Bergkamen (full scale HPLC-production unit).
Since October 1999 working for LONZA as a development chemist (process R&D). Specialist for chromatography and DSP.
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Modeling and Optimization of the Twin Column Capture SMB Process
| Daniel BAUR (ETH ZÜRICH, Zurich, Switzerland) Read more
Daniel Baur was born in 1988 in Zurich, Switzerland. He graduated with a bachelor's degree in 2010 and finished the master curriculum Chemical and Bioengineering in 2011, both at ETH Zurich. In the course of his studies, he completed a research project in the field of colloidal sciences (Numerical modeling of the aggregation of colloidal clusters consisting of nanoparticles in the presence of convective transport) under the supervision of Dr. Marco Lattuada and he produced a master thesis in the fields of chromatography and control (Model Predictive Control of the Multicolumn Countercurrent Solvent Gradient Purification Process with Limited Feedback), under the supervision of Martin Krättli and Prof. Massimo Morbidelli. In the beginning of 2012, he joined the Morbidelli group at the Institute for Chemical and Bioengineering of ETH Zurich for his PhD studies, working in the field of multi-column chromatographic processes, with a focus on process design, simulation, optimization and control. Close window
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Overcoming Challenges in the Industrial Production of OMEGA-3S
| Jean BLEHAUT (NOVASEP GROUP, Pompey, France) |
Advances in Model-Based Inline Peak Deconvolution: Process-Data-Based Model Calibration and Real-Time Pooling Decisions
| Nina BRESTRICH (KARLSRUHE INSTITUTE OF TECHNOLOGY, Karlsruhe, Germany) Read more
Nina Brestrich earned her diploma for Biochemical Engineering at the Karlsruhe Institute of Technology in 2012. During her diploma thesis, she worked on the parameter determination for sorption modelling in hydrophobic interaction chromatography at the Institute of Process Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering. Afterwards, she became a PhD student in the same group. During her PhD project, Nina Brestrich is working on the establishment of Process Analytical Technologies in chromatography. She focuses on the application of multivariate data analysis and spectral measurements for real-time monitoring and control of chromatography processes. In addition, she is also working on cause of error diagnostics in chromatography using chromatography modelling. Close window
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Peptide Purification Via Ion-Exchange Doped Reversed Phase Chromatography: a Combined Experimental and Modeling Approach
| Gianluca BUFFOLINO (ZEOCHEM AG, Uetikon am See, Switzerland) Read more
Gianluca Buffolino was born in 1989 in Zurich, Switzerland. He graduated with a bachelor's degree in 2012 at the Zürcher Fachhochschule für Angewandte Wissenschaften (ZHAW). After his degree he started as projectleader at the Zeochem AG in Uetikon (Switzerland). The huge part of his job was to synthesize new reversed phases on spherical Silicagel and to compare with the main phases on the market. Close window
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Extraction-Injection: an Alternative Sample Introduction Method for SFC
| Geoffroy COX (PIC SOLUTION, Media, United States) Read more
After having earned a PhD in organic electrochemistry at the University of Sheffield and spent 2 years as a photochemistry postdoc at the University of Reading, Dr Cox joined the Laboratory of the Government Chemist where he spent some years in R&D in the then new field of HPLC. He joined DuPont as a European Applications Chemist for their HPLC instrument business before transferring to their HPLC R&D group in the USA. He joined Prochrom as Director R&D where he worked on Simulated Moving Bed systems and subsequently became Director of Technology at Chiral Technologies, Europe. In 2001 he returned to the USA as Vice President, Technology at Chiral Technologies Inc. He started the US subsidiary of PIC Solution SAS of Avignon, France in 2011 and is currently President of PIC Solution Inc. His current research interests are in the development of new technologies, techniques and instrumentation in SFC. Close window
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Implementation of Continuous Chromatography Under cGMP for the Pharmaceutical Industry
| Olivier DAPREMONT (AMPAC FINE CHEMICALS, Rancho Cordova, United States) Read more
Dr Dapremont received his Ph.D. degree in Chemical Engineering and Applied Chemistry in Simulated Moving Bed technology (SMB) and chiral applications in 1997 from the University of Pierre and Marie Curie in Paris. He started his career, in 1992, developing SMB technology for Prochrom R&D then joined in 1997 Chiral Technologies Europe, as manager of the SMB kilo lab. Olivier joined Aerojet Fine Chemicals, now AMPAC Fine Chemicals (AFC) in Rancho Cordova, CA, at the beginning of 2001. At AFC, Dr Dapremont is in charge of the development of chromatographic processes as well as continuous chemistry for APIs and intermediates. To this day, he has developed and implemented more than 20 chiral and non-chiral separations using SMB from kilogram to multi ton scale. Close window
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HTS Chromatographic Platforms: Small is Beautiful
| David DELVAILLE (MERCKSERONO, Martillac, France) Read more
David Delvaille studied biotechnology and received his engineer degree at ENSTBB (Bordeaux Biotech school) before joining Serono based in Martillac (Bordeaux's area). After acquisition of Serono by Merck KgAa and the decision to turn the site to production of biomolecule using microorganisms, he became Dowstream supervisor in the Process Development group. Responsible for development of processes from tox phase up to phase III and ensuring technical transfers at large scale. His interests moved towards the assessment and integration of New technologies in the filed of process downscaling, technically mandatory to ensure QbD approaches applied in Merck Serono's Biotech processes. His group develops future platform that should ensure fast, reliable and cost effective processes for large scale production. Close window
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Methodology for Scale-Up in Countercurrent Chromatography
| Karine FAURE (INSTITUT DES SCIENCES ANALYTIQUES, Villeurbanne, France) Read more
Karine Faure received her Ph.D. in Analytical Chemistry from the University College Cork, Ireland in 2005 and since then she is research associate tenured from the French National Center for Scientific Research (CNRS). Senior Scientist in the Chromatography group in the Department for Separation Sciences of the CNRS Institute of Analytical Sciences (ISA), University of Lyon, France. Her research focuses on centrifugal partition chromatography and especially novel solvents. Close window
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Modelling and Simulation of the Purification of Cell Culture-Derived Influenza Virus Via Continuous Size Exclusion Chromatoghraphy
| Laura M. FISCHER (MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany) Read more
Laura M. Fischer earned her diploma for Biosystems Engineering at the Otto von Guericke University Magdeburg in 2011. Thereafter she joined the Bioprocess Engineering group of the Max Planck Institute for Dynamics of Complex Technical Systems in Magdeburg to work on cell culture-based influenza vaccine production systems. She focuses on downstream processes, in particular continuous chromatography and their mathematical simulation. Since 2012, Laura M. Fischer is a PhD student in the International Max Planck Research School Magdeburg for Advanced Methods in Process and Systems Engineering (IMPRS ProEng). Close window
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Reliable Scale-Up from Analytical to Large Scale Instrumentation in Chiral Supercritical Fluid Chromatography
| Torgny FORNSTEDT (KARLSTAD UNIVERSITY, Karlstad, Sweden) Read more
Torgny Fornstedt is a professor in Analytical Chemistry at Karlstad University, Sweden. He obtained a M.Sc. in Pharmacy at Uppsala University 1986, obtained a PhD in Analytical Pharmaceutical Chemistry at Uppsala University 1992 and was promoted to professor in Analytical Biotechnology at Uppsala University 2008.
Torgny Fornstedt heads the internationally competitive Fundamental Separation Science Group (www.separationscience.se) at Karlstad University. The goal of the group is to conduct theoretically advanced fundamental research in the field of separation science and to cooperate with industry regarding purification of drug molecules and high-value chemicals. The group cooperate both with leading academic groups in Europe and USA and with leading companies. Specifically the group develops and applies numerical tools to characterize, validate and optimize analytical and preparative separation methods important for analytical chemists, biochemists and pharmaceutical chemists. The group is currently working with liquid chromatography (HPLC/UHPLC), Supercritical Fluid Chromatography (SFC) and biosensors (SPR/QCM). Two recent joint projects with AstraZeneca R&D in Mölndal aim (i) at linking solid separation theory in Quality by Design (QbD) of analytical processes and (ii) at deeper understanding and reliable scale up of SFC.
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Preparative Chiral Chromatography. Summa Chiralogica
| Pilar FRANCO (CHIRAL TECHNOLOGIES, INC, ILLKIRCH, France) Read more
Dr. Pilar Franco is the Technical Operations Manager at Chiral Technologies Europe (CTE). Pilar is an expert in the separation of enantiomers by chromatography at the analytical and preparative scale, and she oversees all technical operations for Chiral Technologies Worldwide. She joined CTE in 2002 as a Product Manager having previously worked with Ciba-Geigy (Basel, Switzerland), now known as Novartis, and in research and development with Almirall Prodesfarma (Barcelona, Spain).
Dr. Franco earned her Ph.D. in Pharmacy from the University of Barcelona, studying the preparation and use of polysaccharide derivatives as chiral stationary phases for HPLC. As a Marie Curie Fellow from the European Commission, she also performed postdoctoral work on chiral separations with Dr. W. Lindner at the University of Vienna. Dr. Franco has authored more than 30 publications and five book chapters in her area of expertise.
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Continuous Manufacturing in Biopharmaceutical Industries
| Holger FROEHLICH (CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany) |
Implementation of Model-Based Approach for Chromatography Development
| Bertrand GUELAT (NOVARTIS PHARMA AG, Basel, Switzerland) Read more
Bertrand Guélat received his Master of Sciences degree in Chemical and Biological Engineering from the Swiss Institute of Technology of Lausanne (EPFL), Switzerland, in 2007. He then specialized in the field of protein chromatography during his doctoral studies under the supervision of Prof. Massimo Morbidelli at ETH Zurich, Switzerland. During this time, he focused on the development of adsorption models for ion-exchange chromatography. The main applications were the simulation of charge variants separation of monoclonal antibodies, where the effects of the pH and the salt concentration were explicitly modelled.
He obtained his PhD in 2012 and moved to a Postdoc position in the department of Biologics Process R&D at Novartis Pharma in Basel, Switzerland. There, he is responsible for the implementation of model-based development methods for protein chromatography.
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pH Zone Refining in Centrifugal Partition Extraction. A Step Change in Productivity for Liquid-Liquid Chromatography Processes?
| Paul HELLIER (INSTITUT DE RECHERCHE PIERRE FABRE, GAILLAC, France) Read more
Paul Hellier studied chemistry (B.Sc and Ph.D) at the University of Sheffield in the UK. His academic research experience was supplemented through post-doctoral posts at Brigham Young University in the U.S. and Milan University in Italy. He has pursued a career in Process R&D within the pharmaceutical industry. This has included positions at Boots Pharmaceuticals, BASF, Rhodia and Pfizer. Since 2004 he has been employed by the Pierre Fabre group in France where his current responsibilities include management of late stage process development projects, process safety and technology development activities within the company’s active ingredient Process R&D division. He has particular interests in continuous processing and separation/purification technologies. Close window
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A New Dynamic Fractionation Method and Column Design for Size Separation of Bio-Polymer Particles
| Peter HEWITSON (BRUNEL INSTITUTE FOR BIOENGINEERING, Uxbridge, United Kingdom) Read more
Dr Hewitson is a Bioprocess Engineer in the Institute of Health, Environment and Societies at Brunel University, London. His research focuses on the scale up of continuous liquid-liquid extraction technology for the separation of novel chemicals and bio-molecules for industry use. Recent research also focused on the fractionation of various particles in liquid flow for the pharmaceuticals industry to supply uniform seed crystals and for the health care industry that requires mono-disperse distributions of particles for improved diagnostic sequencing applications. He previously worked as a Senior Research Scientist at Kodak European Research Laboratories where he developing and patented novel photographic media, flexible display and flexible solar cell technology. Close window
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Three Column Intermittent Simulated Moving BED (3C-ISMB) Cromatoghraphy: Cascade Operation for Center-Cut Separations
| Simon JERMANN (ETH ZÜRICH, Zurich, Switzerland) Read more
Simon Jermann received his Bachelor degree in Chemical Engineering from ETH Zurich in 2008 after spending parts of his education at Imperial College London. He continued his studies at ETH Zurich within the Excellence Scholarship and Opportunity Programme and graduated 2009 with a Master degree in Chemical and Bioengineering. After his master thesis under the supervision of Prof. Dr. Manfred Morari (Automatic Optimizing Control of Simulated Moving Bed (SMB) Chromatography) he joined Prof. Dr. Marco Mazzotti's group to continue his research in the field of chromatography. His main research interest is the development of new intermittent SMB processes to both enhance the performance of binary separations and facilitate ternary separations. Besides that, he is interested in the quantitative description of the Delta-shock phenomenon. Close window
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Design of an Agarose Based Platform for Large Scale Chromatography
| Hans JOHANSSON (PUROLITE, Uppsala, Sweden) Read more
Hans J Johansson is application manager at Purolite R&D, Llantrisant, Wales. He has over thirty years experience in the biotech industry. He has spent most of his professional career in research and development with a special focus on industrial chromatography applications. He frequently publishes in scientific papers and is the holder of many patents and patent applications in the area of resin design and large scale protein purification. He is currently working with the design and development of a new, agarose-based, chromatography platform. Close window
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Integration of Continuous Precipitation and Flow Through Chromatography with Monoliths for Purification of Recombinant Antibodies
| Alois JUNGBAUER (UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, Vienna, Austria) Read more
Professor Alois Jungbauer received his PhD in Food Technology and Biotechnology from the University of Natural Resources and Life Sciences Vienna, Austria 1986. He serves since then as a professor at the Department of Biotechnology. He teaches Protein Technology and Downstream Processing and Biochemical Engineering. Professor Jungbauer is head of the laboratory for Protein technology and Downstream Processing. He also acts as area head and Dep. Director of Research in the Austrian Centre of Industrial Biotechnology. He is currently working in the field of bioengineering of proteins, plasmids and viruses with special focus on expression, downstream processing and characterization of large biomolecules. As a proliferate researcher he has more than 250 publications on recombinant protein production and bioseparation, 15 patents and 12 book contributions and recently a monograph entitled “Protein Chromatography , Process Development and Scale Up”. He is executive editor and co-founder of Biotechnology Journal, and member of editorial boards from numerous journals in the area of biochemical engineering. Close window
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Optimizing the Separation of MAB Charge Variants Using Model-Based Approaches
| Rushd KHALAF (ETH ZÜRICH, Zurich, Switzerland) Read more
Rushd Khalaf grew up in Montréal, Québec, Canada. From 2006 to 2010, he attended McGill University in Montréal, graduating with a B.Eng. in chemical engineering, having completed projects in the fields of pulp and paper and thermodynamics. In the fall of 2010, he joined the ETH in Zurich for master level studies. He completed his master thesis, entitled “Experimental Study and Modeling of a Purification Process”, in the Morbidelli Group. He obtained a Master of Science degree from the ETH in chemical and bio-engineering in early 2012. Shortly after, he joined the Morbidelli group as a PhD candidate, working towards better understanding and application of chromatographic processes. Close window
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Purification of an Intermediately Eluting Component from a Complex Mixture
| Kiara KOCHENDOERFER (BASF SE, Ludwigshafen, Germany) Read more
Kiara Kochendörfer studied process engineering at Technische Universität Berlin. During her studies, she went to Imperial College London and National University of Singapore at the Department of Chemical Engineering. After her graduation in 2009, she was PhD student in the group of chromatography under the supervision of Prof. Dr. Arlt in Erlangen at the Friedrich-Alexander-University Erlangen-Nuremberg. Her research topic was “Purification of an Intermediately Eluting Component from a Complex Mixture”. In 2013, Kiara joint BASF and continued working in the field as a research engineer in the Team Adsorption and Ion Exchange. Close window
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Separation of Lignans by Supercritical Fluid Simulated Moving BED
| Ming-Tsai LIANG (I-SHOU UNIVERSITY, Kaohsiung, Taiwan) Read more
Dr. Ming-Tsai Liang has been an associate professor of Chemical Engineering at I-Shou University since 1991. He received his MS & PhD in Chemical Engineering from Clarkson University (New York) in 1991. He has worked in the applications of supercritical fluids related technologies since 1991, and began to work on simulated moving bed in 2004. He is currently establishing a research center, Center for Advanced Chromatographic Separation Processes, in I-Shou University. He also serves as a consultant to Metal Industries Research and Development Centre of Taiwan, Industrial Technology Research Institute of Taiwan, and several instrument, chemical, food, and pharmaceutical companies in Taiwan and in China. Close window
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Implementing Integrated Continuous Downstream Processing
| Kathleen MIHLBACHLER (LEWA GMBH, Leonberg, Germany) Read more
Dr. Mihlbachler has worked in the field of process chromatography for more than 15 years. Currently, she is the Global Director of Separations Development at LEWA Process Technology – A member of LEWA-Nikkiso Group. She is responsible for the development of separation technologies for synthetic and biological molecules, in particular for continuous processing. Prior to this appointment Dr. Mihlbachler worked as an external consultant for LEWA-NIKKISO since 2012 where she has supported the technical transfer of process chromatographic technology and consulted in customer projects.
Previously, Dr. Mihlbachler was involved as a Sr. Researcher at BMS, Eli Lilly and Pfizer in the development, scale-up and manufacturing of purification/separation processes for chiral and non-chiral compounds, peptides and proteins, in particular to implement continuous processes. From
2011 to 2013, Dr. Mihlbachler has taught undergraduate courses for chemical and biomedical students in the Department of Chemical, Biological and Pharmaceutical Engineering at New Jersey Institute of Technology.
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From Molecule to Process: Model-Based Design of Continuous Centrifugal Partition Chromatography
| Mirjana MINCEVA (TECHNISCHE UNIVERSITÄT MÜNCHEN, Freising, Germany) Read more
Prof. Minceva studied Food science and biotechnology and Process engineering in Macedonia at the University Ss. Ciryl and Methodius.
In 2004, she completed her PhD at the University of Porto (Portugal) in the group of Prof. Alirio Rodrigues.
Subsequently she worked as an associate scientist in the same group and NATO Postdoctoral fellow in Macedonia.
Between 2007 and 2014, she led the Chromatography group at the Chair of Separation Science and Technology (Prof. Wolfgang Arlt), University of Erlangen-Nuremberg, where she received her lecturer qualification in 2013.
She was appointed assistant professor at Technische Universität München in July 2014.
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Purification of Antibody Conjugates by MCSGP Chromatography
| Thomas MÜLLER-SPÄTH (CHROMACON AG, Zurich, Switzerland) Read more
Thomas Müller-Späth, Dr. sc. ETH, Dipl.-Ing., holds a COO position at ChromaCon AG, Switzerland. He finished his studies in chemical engineering with a diploma thesis in the area of fermentation technology at the Technical University Hamburg, Germany. During a 1-year stay at the University of California, Berkeley (USA), he deepened his knowledge in biotechnology. During an 8-month internship in the Factor-VIII production at Bayer Healthcare in Berkeley (USA), he investigated the application of chromatography for purification and participated in further education in the area of GMP (Good Manufacturing Practice). Thomas obtained his PhD in the area of continuous chromatography for the purification of proteins in October 2008 under the guidance of Prof. Morbidelli. Close window
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Modelling and Optimization of Preparative Chromatography Separation of Rare Earth Elements
| Bernt NILSSON (LUND UNIVERSITY, Lund, Sweden) Read more
Prof. Bernt Nilson is professor at Department of Chemical Engineering, Lund University, Sweden. His research activities are in the field of mathematical modelling and simulation techniques, model calibration and optimization techniques, model based operation and control, model based engineering and computer tools with m ain applications:in protein chromatography for biopharmaceutical applications, and industrial chromatographic systems in pharmaceutical industries. He also conducts Industrial courses in industrial process simulation and process engineering. He has more than 70 peer reviewed publications in the field of process engineering and chromatography. Close window
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High Yeld Protein Refolding by Integrating Single-Column Chromatoghraphy and Membrane Filtration
| Sebastian NIMMIG ( FRIEDRICH-ALEXANDER-UNIVERSITY, Erlangen, Germany) Read more
Mr. Sebastian Nimmig studied process engineering at the Otto-von-Guericke University in Magdeburg, Germany. He obtained his Diploma in 2011. Subsequently he became a researcher at the Institute of Separation Science and Technology in Erlangen, Germany, at the group of Prof. Kaspereit. Currently Mr. Nimmig is doing his research in the field of integrating chromatography, membrane processes and biochemical reactions to graduate as PhD. Close window
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Hardware Solutions Enabling Continuous Biomanufacturing
| Roger NORDBERG (GE HEALTHCARE, Uppsala, Sweden) Read more
Roger Nordberg received his MS in Chemistry and Physics from Uppsala University, Sweden. Joined GE in 1984 and is currently Sr. Product Manager Bioprocess Hardware within Life Sciences, responsible for developing continuous process technologies. Roger is experienced in downstream processing, process optimization and validation. Close window
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Integrated Reaction/Separation Process for High-Yield Pegylation
| David PFISTER (ETH ZÜRICH, Zürich, Switzerland) Read more
David Pfister was born in Nancy, France on March 5, 1988. From 2006 to 2008, he prepared the entrance examinations to the French Grandes Ecoles for science and engineering. Between 2008 and 2011, he studied Chemical Engineering at the ENSIC of Nancy, France. In December 2011, he graduated as "Diplôme d'Ingénieur" equivalent to Master of Science in Chemical Engineering. He carried out his master's thesis at the ETH Zürich in the group of Prof. Dr. Morbidelli under the supervision of Stefano Lazzari. The title of this project was "Modeling of non-linear free-radical copolymerization of monovinyl and divinyl monomers". In February 2012, he joined the group of Prof. Morbidelli as a PhD student in the field of "Proteins Purification" applied to the chromatographic purification of PEGylated proteins. Close window
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Unified Design of Chromatographic Separation Processes
| Tuomo SAINIO (LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland) Read more
Tuomo Sainio is currently professor in Laboratory of Separation Technology at Lappeenranta University of Technology (LUT), Finland. He earned his doctor of science degree from the LUT Laboratory of Industrial Chemistry at 2005. His research interests range from the fundamental phenomena in chromatography, ion exchange, and solvent extraction to development of process design methods for integrated separation processes. Main application areas are in biorefining and metal separations. Close window
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Implementation of a Negative Mode Platform for Virus Purification
| Ricardo SILVA (IBET - INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECHNOLOGICA, Oeiras, Portugal) Read more
Ricardo Silva received his Master degree in Chemical and Biochemical Engineering from Faculdade de Ciências e Tecnologia – Universidade Nova de Lisboa in 2008. His Phd studies, developed under the supervision of Prof. José Paulo Mota, focused on the development and optimization of countercurrent adsorption processes.
At the moment, he is a post-doc at Animal Cell Technology Unit in iBET, working in downstream processing targeting continuous purification processes and identification of new purification strategies for viral vaccines and vectors.
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Saturation Capacity for Proteins in Ion Exchange Chromatoghraphy
| Fabian STEINEBACH (ETH ZÜRICH, Zurich, Switzerland) Read more
Fabian Steinebach grew up in Konstanz, Germany. In 2008 he joined ETH Zurich to study chemical engineering. He obtained his MSc in Chemical and Bioengineering in 2012, after completing his master thesis, entitled “Development of a PID controller for the twin-column MCSGP process” in the Morbidelli group. In 2012 he became a PhD candidate under supervision of Prof. Morbidelli, working on multi-column chromatography and fundamental understanding of ion exchange chromatography. Close window
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Scale-Up in Supercritical Fluid Chromatography
| Abhijit TARAFDER (WATERS CORPORATION, Milford, United States) Read more
Dr Abhijit Tarafder works as a Principal Research Chemist in Waters Corporation. After working on prep RPLC and SMB, in 2010 he moved to USA to work with Prof Georges Guiochon on SFC. He has authored or co-authored 32 articles in archival peer-reviewed journals out of which 18 were on SFC and published during the last four years in J Chromatography A. His work focuses on understanding the physical behavior of SFC systems and how that knowledge can be applied to design better separation in SFC. Close window
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Continuous Processing of Self-Cleaving Fusion Proteins by Matrix-Assisted Refolding Separation Using SMB Size Exclusion Chromatography with Buffer Recycling
| Martin WELLHÖFER (CELONIC AG, Basel, Switzerland) Read more
Martin Wellhöfer studied biochemical engineering at the technical University of Karlsruhe (KIT), Germany, before he joined the working group of Prof. Alois Jungbauer at the University of Natural Resources and Life Sciences Vienna (BOKU), Austria. After receiving his PhD in 2013 he joined Celonic AG in Basel, Switzerland, where he is currently heading the DSP department responsible for process development and GMP production. Close window
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Integrated Counetr Current Chromatography (ICCC) - From SMB to a Fully Integrated Process
| Steffen ZOBEL (CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany) Read more
Steffen Zobel was born in 1987. He studied process engineering at the Technical University of Clausthal and finished his studies in 2012 with the academical degree of Diplom Ingenieur. At the moment, He is a scientific assistant at the institute for separation and process technology at the technical university of clausthal. His field of research for his PhD studies under Prof. Strube are adsorptive processes, especially continuous chromatography. Close window
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Workshops
From Development to Commercial Scale:
Rules to Scale up, QbD, Regulatory, Process Validation
Process Design for Purification of Biomolecules
| Alois JUNGBAUER (UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, Vienna, Austria) Read more
Professor Alois Jungbauer received his PhD in Food Technology and Biotechnology from the University of Natural Resources and Life Sciences Vienna, Austria 1986. He serves since then as a professor at the Department of Biotechnology. He teaches Protein Technology and Downstream Processing and Biochemical Engineering. Professor Jungbauer is head of the laboratory for Protein technology and Downstream Processing. He also acts as area head and Dep. Director of Research in the Austrian Centre of Industrial Biotechnology. He is currently working in the field of bioengineering of proteins, plasmids and viruses with special focus on expression, downstream processing and characterization of large biomolecules. As a proliferate researcher he has more than 250 publications on recombinant protein production and bioseparation, 15 patents and 12 book contributions and recently a monograph entitled “Protein Chromatography , Process Development and Scale Up”. He is executive editor and co-founder of Biotechnology Journal, and member of editorial boards from numerous journals in the area of biochemical engineering. Close window
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Multicolumn Processes:
From Historical SMB to the Latest Advances in the Purification of Biomolecules
| Arvind RAJENDRAN (UNIVERSITY OF ALBERTA, Edmonton, AB, Canada) |
Preparative HPLC:
Phase Screening, Method Optimisation, Process Development. Troubleshooting a Preparative Chromatographic Device
| Michael SCHULTE (MERCK KGAA, Darmstadt, Germany) |
Process Design for Purification of Small Molecules and Peptides
| Jochen STRUBE (CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany) |
Solving a Purification Process:
Choice of the Appropriate Process (Centrifugal Partition Chromatography vs Countercurrent Chromatography, Batch vs Continuous, Low Pressure vs High Pressure, Liquid vs SFC)
| Eric VALERY (NOVASEP, Pompey, France) |
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