| Sunday October 9, 2016 |
| 13:00 | Registration |
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| Workshop 1 | Workshop 2 |
| 14:00 | Preparative HPLC of Peptides and Small Molecules: Phase Screening, Method Optimisation, Process Design |
Michael SCHULTE (MERCK KGAA, Darmstadt, Germany)
Jochen STRUBE (CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany) |
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| 15:30 | Coffee Break |
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| Workshop 3 | Workshop 4 |
| 16:00 | Multicolumn Processes: From Historical SMB to the Latest Advances in the Purification of Biomolecules |
Massimo MORBIDELLI (ETH ZÜRICH, Zürich, Switzerland)
José Paulo MOTA (UNIVERSIDADE NOVA DE LISBOA, Caparica, Portugal)
Arvind RAJENDRAN (UNIVERSITY OF ALBERTA, Edmonton, AB, Canada) |
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| Process Design for Purification of Biomolecules |
Alois JUNGBAUER (UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, Vienna, Austria)
Bernt NILSSON (LUND UNIVERSITY, Lund, Sweden) |
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| 17:45 | SPICA 2016 Opening Ceremony |
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| 18:00 | KL01 - Current Innovation Challenges in the Development of non-Mab Biotherapeutics |
Georg KLIMA
(BOEHRINGER INGELHEIM, Vienna, Austria) |
| 18:45 | Welcome Reception |
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| 20:00 | End of the Day |
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| Monday October 10, 2016 |
| 08:00 | Registration |
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| Session 1 |
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| Session Chair |
Bernt NILSSON
(LUND UNIVERSITY, Lund, Sweden) |
| 09:00 | KL02 - What Can We Learn from Art in the Better Design of Production Equipment for Biopharmaceuticals? |
Martin HOFMANN
(BIOTECHFLOW, Stroud, Glos, United Kingdom) |
| 09:40 | OC01 - Viscous Fingering Dynamics in Preparative Liquid Chromatography
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Michel MARTIN
(ECOLE SUPÉRIEURE DE PHYSIQUE ET CHIMIE/CNRS/PMMH, Paris, France) |
| 10:00 | OC02 - Computational Fluid Dynamics Study of Viscous Fingering in Supercritical Fluid Chromatography
|
Arvind RAJENDRAN
(UNIVERSITY OF ALBERTA, Edmonton, AB, Canada) |
| 10:20 | Coffee Break & Exhibition |
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| Session 2 |
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| Session Chair |
Jochen STRUBE
(CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany) |
| 10:50 | OC03 - Unified Design of Chromatographic Separation Processes
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Tuomo SAINIO
(LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland) |
| 11:10 | OC04 - Application of Expanded Bed to the Production of Industrial Enzymes
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Esteban FREYDELL
(DSM , Delft, The Netherlands) |
| 11:30 | OC05 - Some Insights in Centrifugal Partition Chromatography Engineering - Application to Alkaloids Separation at Production Scale
|
Luc MARCHAL
(UNIVERSITÉ DE NANTES, Saint Nazaire, France) |
| 11:50 | OC06 - Simultaneous Optimization of Chromatographic Process Configuration and Operating Conditions
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Johannes SCHMÖLDER
(FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG, Erlangen, Germany) |
| 12:10 | Lunch Break & Exhibition |
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| 12:20 | Vendor Seminars by Agilent Technologies, Daiso Fine Chem & Rotachrom Technologiai (12:20-13:20) |
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| Session 3 |
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| Session Chair |
José Paulo MOTA
(UNIVERSIDADE NOVA DE LISBOA, Caparica, Portugal) |
| 13:30 | KL03 - Design and Control of Continuous Downstream Processing for Cost Efficient Manufacturing of Biopharmaceuticals |
Oliver KALTENBRUNNER
(AMGEN INC., Thousand Oaks, United States) |
| 14:10 | OC07 - Investigation and Development of Preparative Recycling Size Exclusion Chromatography
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Kathleen MUELLER
(FRIEDRICH-ALEXANDER UNIVERSITÄT ERLANGEN-NÜRNBERG, Erlangen, Germany) |
| 14:30 | OC08 - Modelling Scale-Up of Preparative Chromatography Columns Taking into Account Extra Column Effects and Variations of Packing Quality
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Susanne SCHWEIGER
(AUSTRIAN CENTRE OF INDUSTRIAL BIOTECHNOLOGY, Vienna, Austria) |
| 14:50 | OC09 - Scalability of Mechanistic Models for Ion Exchange Chromatography under Highly Overloaded Conditions
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Thiemo HUUK
(KARLSRUHE INSTITUTE OF TECHNOLOGY (KIT), GOSILICO, Karlsruhe, Germany) |
| 15:10 | Coffee Break & Exhibition |
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| Session 4 |
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| Session Chair |
Dorota ANTOS (RZESZOW UNIVERSITY OF TECHNOLOGY, Rzeszow, Poland)
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| 15:40 | KL04 - Continuous Purification Platforms for Viral Vectors Based on Multicolumn Simulated Countercurrent Chromatography |
José Paulo MOTA
(UNIVERSIDADE NOVA DE LISBOA, Caparica, Portugal) |
| 16:20 | OC10 - When Scaling-Up Chromatography is not Trivial
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Roger-Marc NICOUD
(YPSO-FACTO, Nancy, France) |
| 16:40 | OC11 - Development of a Continuous Downstream Cascade for the End-to-End Integrated Manufacture of Monoclonal Antibodies
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Fabian STEINEBACH
(ETH ZÜRICH, Zurich, Switzerland) |
| 17:00 | OC12 - Continuous Integrated Antibody Digestion and Purification |
Nicole ULMER
(ETH ZURICH, Zurich, Switzerland) |
| 17:20 | Poster Session 1 (even numbers) & Beer Party |
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| 18:20 | End of the Day |
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| Tuesday October 11, 2016 |
| Session 5 |
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| Session Chair |
Massimo MORBIDELLI
(ETH ZÜRICH, Zürich, Switzerland) |
| 08:30 | KL05 - Understanding Protein Unfolding and Aggregation in Cation Exchange and Protein A Chromatography Columns |
Giorgio CARTA
(UNIVERSITY OF VIRGINIA, Charlottesville, United States) |
| 09:10 | OC13 - Preparative Separation and Characterization of Charge Variants of Several Blockbuster Antibody Therapeutics
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Nico LINGG
(UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, VIENNA, Vienna, Austria) |
| 09:30 | OC14 - Polyvalent Buffers in Ion Exchange Chromatography Using Salt Tolerant Resins
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Egbert MÜLLER
(TOSOH BIOSCIENCE GMBH, Darmstadt, Germany) |
| 09:50 | OC15 - Effect of Isotherm Nonlinearity on the Retention Behaviour of Proteins in Hydrophobic Interaction and Multimodal Chromatography
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Dorota ANTOS
(RZESZOW UNIVERSITY OF TECHNOLOGY, Rzeszow, Poland) |
| 10:10 | OC16 - SMB Separation of Peptides |
Joachim KINKEL
(GEORG-SIMON-OHM UNIVERSITY OF APPLIED SCIENCES, Nuernberg, Germany) |
| 10:30 | Coffee Break & Exhibition |
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| Session 6 |
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| Session Chair |
Joachim KINKEL
(GEORG-SIMON-OHM UNIVERSITY OF APPLIED SCIENCES, Nuernberg, Germany) |
| 11:00 | OC17 - General Gradients for Preparative Protein Chomatography |
Bernt NILSSON
(LUND UNIVERSITY, Lund, Sweden) |
| 11:20 | OC18 - PAT for Preparative Chromatography of Proteins: Real-Time Monitoring of a Capture and Polishing Step
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Matthias RÜDT
(KARLSRUHE INSTITUTE OF TECHNOLOGY, Karlsruhe, Germany) |
| 11:40 | OC19 - Pore Diffusion Coefficients of Proteins in Multicomponent Mixtures
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Alexander MATLSCHWEIGER
(BOKU VIENNA, Vienna, Austria) |
| 12:00 | OC20 - Improving Washing Strategies of Human Mesenchymal Stem Cells Using Negative Mode Expanded Bed Chromatography |
Cristina PEIXOTO
(IBET, Oeiras, Portugal) |
| 12:20 | Lunch Break sponsored by AMPAC Fine Chemicals & Exhibition |
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| 12:30 | Vendor Seminars by AKZO Nobel/Kromasil & Chiral Technologies Europe (12:30-13:30) |
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| 13:40 | Poster Session 2 (odd numbers) |
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| Session 7 |
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| Session Chair |
Michael SCHULTE
(MERCK KGAA, Darmstadt, Germany) |
| 14:40 | KL06 - Strategies for Improving the Productivity of Chromatography or Proteins |
Shuichi YAMAMOTO
(YAMAGUCHI UNIVERSITY, Ube, Japan) |
| 15:20 | OC21 - Optimization of Primary Recovery and Downsteam Processing for Protein Purification from E. Coli Homogenates
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Rainer HAHN
(BOKU VIENNA, Vienna, Austria) |
| 15:40 | OC22- Influence of Mixed Electrolytes and PH on HIC-Adsorption and Partial Molar Volume of Proteins
|
Eva HACKEMANN
(TU KAISERSLAUTERN, Kaiserslautern, Germany) |
| 16:00 | OC23 - Negative and Positive Multi-Column Chromatographic Strategies for the Purification of Enveloped Virus-Like Particles
|
Ricardo SILVA
(IBET - INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECHNOLOGICA, Oeiras, Portugal) |
| 16:20 | Coffee Break & Exhibition |
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| Session 8 |
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| Session Chair |
Andreas SEIDEL-MORGENSTERN
(MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany) |
| 16:50 | OC24 - Model Predictive Control of 4-Zone Simulated Moving Bed Chromatography for the Separation of Bicalutamide Enantiomers
|
Ju Weon LEE
(MAX-PLANCK-INSTITUTE FOR DYNAMICS OF COMPLEX TECHINCAL SYSTEMS, Magdeburg, Germany) |
| 17:10 | OC25 - Concurrent Modeling and Design Approach for Development of Multi-Component Simulated Moving Bed Processes |
Yoshiaki KAWAJIRI
(GEORGIA INSTITUTE OF TECHNOLOGY, Atlanta, United States) |
| 17:30 | OC26 - A Method for Designing Flow-Through Chromatography Processes
|
Sumiko HASEGAWA
(YAMAGUCHI UNIVERSITY, Ube, Japan) |
| 17:50 | OC27 - Simulated Periodic Counter-Current Chromatography (SPCCC) - A Scale-Down Model for Multicolumn Continuous Chromatography Process Development
|
Gang WANG
(KARLSRUHE INSTITUTE OF TECHNOLOGY (KIT), Karlsruhe, Germany) |
| 18:10 | OC28 - Integrated Counter Current Chromatography (iCCC) - A Platform Alternative for a Protein a Free mAB and SCFV Downstream |
Fabian MESTMÄCKER
(TU-CLAUSTHAL, Clausthal-Zellerfeld, Germany) |
| 18:30 | End of the Day |
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| 20:00 | Symposium Banquet |
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| Wednesday October 12, 2016 |
| Session 9 |
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| 08:30 | Session Chair |
Tuomo SAINIO
(LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland) |
| 08:30 | OC29 - Experimental Analysis and Theoretical Description of Multiphase Flow in the Context of Liquid Chromatography
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Franziska ORTNER
(ETH ZURICH, Zurich, Switzerland) |
| 08:50 | OC30 - Ionic Liquid-Liquid Chromatography (ILLC)
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Martyn EARLE
(QUILL RESEARCH CENTRE, Belfast, United Kingdom) |
| 09:10 | OC31 - Ion Exclusion Chromatography: Model Development and Experimental Results
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Gabriele LODI
(POLITECNICO DI MILANO, Casteggio, Italy) |
| 09:30 | OC32 - Tuning of Peak Deformations, Due to Co-Solvent Adsorption, in Preparative Supercritical Fluid Chromatography
|
Torgny FORNSTEDT
(KARLSTAD UNIVERSITY, Karlstad, Sweden) |
| 09:50 | Poster Prizes |
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| 10:10 | Coffee Break & Exhibition |
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| Session 10 |
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| Session Chair |
Eric VALERY
(NOVASEP, Pompey, France) |
| 10:40 | KL07 - The Effect of Column Heterogeneity and Column Structure on the Accuracy of Overloading Studies |
Attila FELINGER
(UNIVERSITY OF PECS, Pécs, Hungary) |
| 11:20 | OC33 - Separation of a Quaternary Chiral Mixture Using Different Simulated Moving Bed Strategies
|
António E. RIBEIRO
(POLYTECHNIC INSTITUTE OF BRAGANÇA, Bragança, Portugal) |
| 11:40 | OC34 - Model-Based Design of Preparative Binary and Ternary Separations with Liquid-Liquid Chromatography
|
Raena MORLEY
(TECHNICAL UNIVERSITY OF MUNICH, Freising, Germany) |
| 12:00 | OC35 - Applying the Ideal Adsorbed Solution Theory to Describe Elution Profiles in Case of Complex Single Component Isotherms
|
Andreas SEIDEL-MORGENSTERN
(MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany) |
| 12:20 | OC36 - Liquid-Liquid Chromatographic Separation of Natural Compounds Using Biphasic Systems Containing Deep Eutectic Solvents: Experimental and Computational Studies
|
Mirjana MINCEVA
(TECHNICAL UNIVERSITY OF MUNICH, Freising, Germany) |
| 12:40 | Closing Remarks |
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