| Tuesday June 7, 2016 |
| 13:00 | Registration |
|
| 14:00 | Welcome Address |
|
| Session 1: Emerging Technologies |
|
| Session Chair |
Dr Chun-wa CHUNG
(GLAXOSMITHKLINE, Stevenage, United Kingdom) |
| 14:15 | Mass Spectrometry and its Role in Drug Discovery (PL01)
|
Prof. Carol ROBINSON
(UNIVERSITY OF OXFORD, Oxford, United Kingdom) |
| 15:00 | A 5-Year Retrospective on Non-Covalent Mass Spectrometry Applied to Drug Discovery (OC01) |
Dr Mathias ANTOINE
(INSTITUT DE RECHERCHES SERVIER, Croissy-sur-Seine, France) |
| 15:25 | Maldi Mass Spectrometry: From Imaging to Ultra-High-Throughput-Screening (Maldi-Uhts) (OC02) |
Dr Jens FUCHSER
(BRUKER DALTONICS, Bremen, Germany) |
| 15:50 | Coffee Break |
|
| 16:20 | Exploring GPCR and Membrane Protein Dynamics with Solution NMR and X-ray Free-Electron Lasers (PL02)
|
Prof. Gebhard F.X. SCHERTLER
(PAUL SCHERRER INSTITUTE, Villigen, Switzerland) |
| 17:05 | Exhibitor Short Presentation: Creoptix AG
The WAVE of the Future in Kinetics |
Dr Matyas VEGH
(CREOPTIX AG, Wädenswil, Switzerland) |
| 17:15 | Exhibitor Short Presentation: Bruker BioSpin
Fragment Screening by Ligand Observed NMR |
Dr Stefan JEHLE
(BRUKER BIOSPIN, Faellanden, Switzerland) |
| Keynote Lecture |
|
| Chair |
Dr Ursula EGNER
(BAYER HEALTHCARE, Berlin, Germany) |
| 17:25 | The Discovery of ABL001, an Allosteric Inhibitor of BCR-ABL (KN01)
|
Dr Sandra JACOB
(NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Basel, Switzerland) |
| 18:25 | Welcome Reception |
|
| Wednesday June 8, 2016 |
| 08:30 | Registration |
|
| Session 2: Biophysics for Challenging Targets |
|
| Session Chair |
Dr Geoff HOLDGATE
(ASTRAZENECA, Macclesfield, United Kingdom) |
| 09:00 | New Strategy for Challenging Targets: Time Resolved Molecular Interaction Analysis on Living Cells Using LigandTracer (PL03)
|
Dr Karl ANDERSSON
(RIDGEVIEW INSTRUMENTS AB, Vänge, Sweden) |
| 09:45 | Exhibitor Short Presentation: Dynamic Biosensors
Biophysical Analysis of Molecular Interactions and Enzymatic Activity with switchSENSE |
Dr Duncan BORTHWICK
(DYNAMIC BIOSENSORS, Martinsried/Planegg, Germany) |
| 09:55 | Combining Binding Thermodynamics and Kinetic Binding Mechanisms to Assess The Selectivity of Inhibitors of Histone Deacetylase-Like Amidohydrolases (OC03) |
Mr Christian MEYNERS
(UNIVERSITY OF APPLIED SCIENCES DARMSTADT, Darmstadt, Germany) |
| 10:20 | Coffee Break |
|
| 10:50 | Thermodynamics of the Ribosome Translation Machinery (OC04) |
Dr Eric ENNIFAR
(CNRS, Strasbourg, France) |
| 11:15 | Exhibitor Short Presentation: Molecular Sensing
Affinity Assays for GPCR ligand binding using TruBind™ Molecular Interaction Analysis |
Dr Yvonne VOLZ
(MOLECULAR SENSING, Idstein, Germany) |
| 11:25 | Probing the Structure and Dynamics of Proteins with Single-Molecule Spectroscopy (PL04)
|
Prof. Ben SCHULER
(UNIVERSITY OF ZURICH, Zurich, Switzerland) |
| 12:10 | Lunch & Networking |
|
| 13:00 | Poster Session 1 |
|
| Session 3: Special Focus on Cryo-EM |
|
| Session Chair |
Dr Ursula EGNER
(BAYER HEALTHCARE, Berlin, Germany) |
| 14:15 | High-Resolution Electron Cryo-Microscopy of Membrane Protein Complexes (PL05) |
Prof. Werner KÜHLBRANDT
(MAX PLANCK INSTITUTE OF BIOPHYSICS, Frankfurt am Main, Germany) |
| 15:00 | Cullin-Ring Ubiquitin E3 Ligase Regulation by the Cop9 Signalosome (OC05) |
Dr Simone CAVADINI
(FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH, Basel, Switzerland) |
| 15:25 | Coffee Break |
|
| 15:55 | Visualizing Dynamic Macromolecular Complexes at High Resolution by Cryo-EM (PL06)
|
Prof. Holger STARK
(MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany) |
| 16:40 | EM in Industry: Expectations and Perspectives (PL07) |
Dr Denis ZEYER
(NOVALIX, Illkirch, France) |
| Keynote Lecture |
|
| Chair |
Dr Herbert NAR
(BOEHRINGER INGELHEIM, Biberach, Germany) |
| 17:10 | X-ray Crystallography: an Ever-Reemerging Technology (KN02)
|
Dr Gerard BRICOGNE
(GLOBAL PHASING LTD., Cambridge, United Kingdom) |
| Thursday June 9, 2016 |
| Session 4: Computational Biophysics |
|
| Session Chair |
Prof. Rod HUBBARD
(UNIVERSITY OF YORK & VERNALIS, Cambridge, United Kingdom) |
| 09:00 | Structural Stability of Protein-Ligand Complexes: Applications in Virtual Screening (PL08)
|
Prof. Xavier BARRIL
(BARCELONA UNIVERSITY, Barcelona, Spain) |
| 09:45 | Exhibitor Short Presentation: BioSolveIT
A Visual Approximation to On-the-Fly Computational Thermodynamic Profiling |
Dr Marcus GASTREICH
(BIOSOLVEIT, St. Augustin, Germany) |
| 09:55 | Diverse Applications of Free Energy Calculations in Drug Discovery (OC06) |
Dr David RINALDO
(SCHRÖDINGER, Mannheim, Germany) |
| 10:20 | Coffee Break |
|
| 10:50 | Uncoupling the Structure-Activity Relationships of Beta-2 Adrenergic Receptor Ligands from Membrane Binding (OC07) |
Dr Callum DICKSON
(NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Cambridge, United States) |
| 11:15 | Exhibitor Short Presentation: Biodesy
Real-time, Solution-based Measurement of Protein Conformational Change |
Dr Tad GEORGE
(BIODESY, San Francisco, United States) |
| 11:25 | Computational Exploration of Protein Dynamics for Ligand Design (PL09) |
Prof. Rebecca WADE
(HEIDELBERG INSTITUTE FOR THEORETICAL STUDIES AND HEIDELBERG UNIVERSITY, Heidelberg, Germany) |
| 12:10 | Lunch & Networking |
|
| 12:55 | Poster Session 2 |
|
| Session 5: Cellular Biophysics |
|
| Session Chair |
Prof. Helena DANIELSON
(UPPSALA UNIVERSITY, Uppsala, Sweden) |
| 14:00 | The Life and Death of Cells: Cellular Bioenergetics for Better Phenotype Based Drug Discovery (PL10)
|
Dr Magnus JANSSON
(SYMCEL SVERIGE AB, Spanga, Sweden) |
| 14:45 | Exhibitor Short Presentation: Sierra Sensors
Introducing MASS-2 for High Performance, High Throughput SPR Analysis |
Dr Sven MALIK
(SIERRA SENSORS, Hamburg, Germany) |
| 14:55 | Exhibitor Short Presentation: NovAliX
Balancing Standard and Unique Services for Drug Discovery |
Dr Frank MOFFATT
(NOVALIX, Illkirch, France) |
| 15:05 | Insulin Degrading Enzyme: Drug Target Engagement in Hela Cells by Cellular Thermal Shift Assay (OC08) |
Dr Adrien HERLEDAN (INSTITUT PASTEUR DE LILLE, Lille, France)
|
| 15:30 | Coffee Break |
|
| 16:00 | Imaging of G-protein Coupled Receptors while Quantifying their Ligand-binding Free Energy Landscape to Mutiple Ligands (PL11) |
Prof. Daniel MÜLLER
(ETH ZÜRICH, Basel, Switzerland) |
| 16:45 | Poster Prizes |
|
| 20:00 | Conference Dinner |
|
| Friday June 10, 2016 |
| Session 6: Biophysics for Biotherapeutics |
|
| Session Chair |
Dr Johannes OTTL
(NOVARTIS INSTITUTE OF BIOMEDICAL RESEARCH, Basel, Switzerland) |
| 09:00 | The Neonatal Fc Receptor (FcRn) Binds Independently to Both Sites of the IgG Homodimer with Identical Affinities (PL12) |
Dr Yasmina ABDICHE
(RINAT-PFIZER, San Francisco, United States) |
| 09:45 | Exhibitor Short Presentation: Malvern Instruments
Innovative Solutions for Biosimilars |
Mr Michel TERRAY
(MALVERN INSTRUMENTS, Orsay Cedex, France) |
| 09:55 | Analysis of Bispecific Interactions with the Switchsense Biosensor (OC09) |
Dr Ulrich RANT
(DYNAMIC BIOSENSORS GMBH, Martinsried/Planegg, Germany) |
| 10:20 | Coffee Break |
|
| 10:50 | Kinetic Excursion Analysis (Kinexa) of Avidity Enhancement of a Multi-Valent Adnectin Binding to Clustered Receptors on Cho Cells (OC10)
|
Dr Lumelle SCHNEEWEIS
(BRISTOL-MYERS SQUIBB, Princeton, NJ, United States) |
| 11:15 | Exhibitor Short Presentation: NanoTemper Technologies
Prometheus NT.48 - The Stability Expert |
Dr François-Xavier OGI
(NANOTEMPER TECHNOLOGIES, Munchen, Germany) |
| 11:25 | Combinatorial SEC, AUC and TEM Approach for the Characterization of mAb Dimers (PL13) |
Dr Arne RUFER
(F. HOFFMANN-LA ROCHE LTD., Basel, Switzerland) |
| 12:10 | Closing Remarks and Departure |
|
