| Sunday August 27, 2017 |
| 09:30 | Excursion 1 |
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| 14:00 | Registration |
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| 14:00 | Excursion 2 |
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| 17:00 | Opening |
Karin BRINER (NOVARTIS, Cambridge, United States)
Erick M. CARREIRA (ETH ZÜRICH, Zürich, Switzerland)
Koen AUGUSTYNS (UNIVERSITY OF ANTWERP, Antwerp, Belgium)
Gene VAISBERG (CHEMBRIDGE CORPORATION, San Diego, United States)
Thierry LANGER (UNIVERSITY OF VIENNA, Vienna, Austria) |
| 17:15 | Opening Lecture
T01 - Photochemistry and Photopharmacology in Medicine |
Dirk TRAUNER
(NEW YORK UNIVERSITY, New York, United States) |
| 18:30 | Welcome Reception |
|
| Monday August 28, 2017 |
| Session chair |
Erick M. CARREIRA
(ETH ZÜRICH, Zürich, Switzerland) |
| 08:30 | T02 - Next-Generation Small Molecule Therapeutics |
James E BRADNER
(NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Cambridge, MA, United States) |
| 09:15 | T03 - Drugging the Undruggable |
Mark BUNNAGE
(VERTEX PHARMACEUTICALS, Boston, United States) |
| 10:00 | OC01 - Stereoselective Peptide Modifications – Efficient Tools for Natural Product and Drug Synthesis |
Uli KAZMAIER
(SAARLAND UNIVERSITY, Saarbrücken, Germany) |
| 10:15 | Coffee Break and Exhibition |
|
| 10:45 | T04 - Bioinspired Asymmetric Catalysis |
Helma WENNEMERS
(ETH ZURICH, Zürich, Switzerland) |
| 11:30 | T05 - Strategies to Facilitate the Discovery of Novel CNS PET Ligands |
Lei ZHANG
(PFIZER, Cambridge, United States) |
| 12:15 | OC02 - Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6 |
Peter ETTMAYER
(BOEHRINGER-INGELHEIM, Vienna, Austria) |
| 12:30 | Lunch and Exhibition |
|
| 13:30 | Poster Session 1 |
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| Session chair |
Helma WENNEMERS
(ETH ZURICH, Zürich, Switzerland) |
| 14:30 | T06 - Single Electron Processes to Enable Organic Synthesis |
Gary A. MOLANDER
(UNIVERSITY OF PENNSYLVANIA, Philadelphia, United States) |
| 15:15 | T07 - Beta-secretase Inhibitors as a Therapy for Alzheimer’s Disease – Where Are We Now? |
Roland BÜRLI
(ASTRAZENECA, Cambridge, United Kingdom) |
| 15:45 | OC03 - Mimicking Nature Complexity with 3D-Fragments Assembly |
Hugues LEMOINE
(EDELRIS, LYON, France) |
| 16:15 | Coffee Break and Exhibition |
|
| 16:45 | PRIZE winner EFMC-YMCS 2016
OC04 - Development of Highly Selective and Reversible Diacylglycerol Lipase Inhibitors |
Freek JANSSEN
(LEIDEN UNIVERSITY, Nijmegen, The Netherlands) |
| 17:00 | T08 - Idea2Data: Augmenting Drug Discovery Efforts through Synthetic Reaction Data Mining and Automation |
Christos A. NICOLAOU
(ELI LILLY, Indianapolis, United States) |
| 17:45 | T09 - A RaPID Way to Discover Pseudo-natural Peptides |
Hiroaki SUGA
(UNIVERSITY OF TOKYO, Tokyo, Japan) |
| 18:30 | Closing of the day |
|
| Tuesday August 29, 2017 |
| Session chair |
Koen AUGUSTYNS
(UNIVERSITY OF ANTWERP, Antwerp, Belgium) |
| 08:30 | T10 - Azidoperfluoroalkanes - Neglected, Stable and Useful Fluorinated Synthons |
Petr BEIER
(ACADEMY OF SCIENCES OF THE CZECH REPUBLIC, Prague, Czech Republic) |
| 09:15 | T11 - HIV-1 Maturation Inhibitors |
Nicholas MEANWELL
(BRISTOL-MYERS SQUIBB, Wallingford, United States) |
| 10:00 | OC05 - Discovery of RG7314, a Vasopressin 1a Receptor Antagonist for the Treatment of Social Communication Deficits in Autism Spectrum Disorders |
Patrick SCHNIDER
(F. HOFFMANN-LA ROCHE, Basel, Switzerland) |
| 10:15 | Coffee Break and Exhibition |
|
| 10:45 | T12 - Organic Synthesis with Rearrangements - Adventures in Total Synthesis |
Nuno MAULIDE
(UNIVERSITY OF VIENNA, Vienna, Austria) |
| 11:30 | T13 - Isosteric-Switch Strategies: New Concepts and Recent Advances |
Thomas C. FESSARD
(SPIROCHEM AG, Zurich, Switzerland) |
| 12:15 | OC06 - Expanding Screening Decks by Innovative MCR Scaffolds |
Alexander DÖMLING
(UNIVERSITY OF GRONINGEN, Groningen, The Netherlands) |
| 12:30 | Lunch and Exhibition |
|
| 13:30 | Poster Session 2 |
|
| Session chair |
Gene VAISBERG
(CHEMBRIDGE CORPORATION, San Diego, United States) |
| 14:30 | T14 - Iron(III)-Catalyzed Carbonyl-Olefin Metathesis |
Corinna SCHINDLER
(UNIVERSITY OF MICHIGAN, Ann Arbor, United States) |
| 15:15 | T15 - Ring Construction by Pd-catalyzed C(sp3)-H Activation |
Olivier BAUDOIN
(UNIVERSITY OF BASEL, Basel, Switzerland) |
| 16:00 | OC07 - The Discovery of Soluble Guanylate Cyclase Stimulators for the Treatment of Pulmonary Arterial Hypertension |
Subharekha RAGHAVAN
(MSD, Kenilworth, New Jersey, United States) |
| 16:15 | Coffee Break and Exhibition |
|
| 16:45 | T16 - Merck Drug Discovery through Enabling Capabilities |
Petr VACHAL
(MSD, Kenilworth, United States) |
| 17:30 | T17 - Adventures in Catalysis: from Mechanisms to Applications |
Franziska SCHOENEBECK
(RWTH AACHEN, Aachen, Germany) |
| 18:15 | Closing of the day |
|
| Wednesday August 30, 2017 |
| Session chair |
Thierry LANGER
(UNIVERSITY OF VIENNA, Vienna, Austria) |
| 08:30 | T18 - Exploiting Physical Organic Principles in Reaction Design |
Ryan GILMOUR
(UNIVERSITY OF MÜNSTER, Münster, Germany) |
| 09:15 | T19 - Automation, Integration and Miniaturization In Drug Discovery Synthesis |
Guido KOCH
(NOVARTIS PHARMA AG, Basel, Switzerland) |
| 10:00 | OC08 - Exploring New Methods for Facile Synthesis of Some Biologically Interesting Molecules |
Ming-Hua XU
(SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Shanghai, China) |
| 10:15 | Coffee Break and Exhibition |
|
| 10:45 | T20 - Design and Evolution of New Biocatalysts for Organic Synthesis |
Nicholas John TURNER
(UNIVERSITY OF MANCHESTER, Manchester, United Kingdom) |
| 11:30 | T21 - With Asymmetric Hydrogenation towards a Scalable, Stereoselective Synthesis of Bitopertin |
Michelangelo SCALONE
(F. HOFFMANN-LA ROCHE AG, Basel, Switzerland) |
| 12:15 | OC09 - Development of Synthesis Strategies to DNA-Encoded Compound Libraries - of a Chemoresistant Sequence, and Micellar Nanoreactors |
Andreas BRUNSCHWEIGER
(TU DORTMUND, Dortmund, Germany) |
| 12:30 | Lunch and Exhibition |
|
| 13:30 | Poster Session 3 |
|
| Session chair |
Yves P. AUBERSON
(NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Basel, Switzerland) |
| 14:30 | T22 - Collaborative Academic/Industrial Research Under the Umbrella of the NSF Center for Selective C-H Functionalization |
Huw DAVIES
( EMORY UNIVERSITY, Atlanta, United States) |
| 15:15 | Roundtable discussion: “Enabling Advances in the Science of Synthesis through Industry-Academic collaborations in the 21st Century” |
|
| 16:15 | Coffee Break and Exhibition |
|
| 16:45 | Prize Ceremony |
Koen AUGUSTYNS
(UNIVERSITY OF ANTWERP, Antwerp, Belgium) |
| 16:50 | EFMC Prize for a Young Medicinal Chemist in Academia
OC10 - Nature-Derived Peptides as Pharmacological Tools to Design Novel Therapeutics |
Christian W. GRUBER
(MEDICAL UNIVERSITY OF VIENNA, Vienna, Austria) |
| 17:35 | EFMC Prize for a Young Medicinal Chemist in Industry:
OC11 - The Development of non-BET Bromodomain Chemical Probes |
Phil HUMPHREYS
(GLAXOSMITHKLINE, Stevenage, United Kingdom) |
| 17:50 | T23 - Strategies towards Increasing the 3-Dimensionality of the Medicinal Chemistry Design Space |
Antonia F. STEPAN
(PFIZER, Cambridge, United States) |
| 18:35 | Closing of the day |
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| 20:00 | Symposium banquet |
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| Thursday August 31, 2017 |
| Session chair |
Karin BRINER
(NOVARTIS, Cambridge, United States) |
| 08:30 | T24 - Synthetic, Mechanistic and Computational Studies on Reactions of Interest |
Scott E. DENMARK
(UNIVERSITY OF ILLINOIS, Urbana, United States) |
| 09:15 | T25 - More Options, More Complexity: Medicinal Chemistry Mastering Mixed Modalities |
Werngard CZECHTIZKY
(SANOFI-AVENTIS DEUTSCHLAND GMBH, Frankfurt, Germany) |
| 10:00 | OC12 - Discovery of UCB0942, the First Rationally Designed Antiepileptic Drug with a Dual Mechanism of Action for the Treatment of Drug-Resistant Epilepsy |
Laurent PROVINS
(UCB, Braine-l'Alleud, Belgium) |
| 10:15 | Coffee break and Exhibition |
|
| 10:45 | T26 - DNA Repair Inhibition in Cancer Therapy: DNA-PK Inhibitor M3814 |
Thomas FUCHSS
(MERCK KGAA, Darmstadt, Germany) |
| 11:30 | T27 - Late Stage 18F-Fluorination for PET Imaging |
Véronique GOUVERNEUR
(UNIVERSITY OF OXFORD, Oxford, United Kingdom) |
| 12:15 | Poster Prizes Ceremony |
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| 12:30 | Closing remarks |
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| 13:00 | End of the Symposium |
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