ASMC'07 St. Petersburg 27/08/2007
Optional tours between 09.00-18.00 / Pushkin (Amber room) + Pavlovsk Palaces, three Cathedrals (tbc), Canals
Transfers from the airport between 12.00-19.00
14:00 Registration
19:30 Welcome reception
28/08/2007
08:30 Opening
09:10 The Changing Face of Organic Synthesis
Prof. Steven V. LEY
10:00 Protecting Group Directed Ring-Closing Metathesis (RCM):
the First Total Synthesis of Anti-Malarial Nonenolide
Dr. Mukund S. CHORGHADE
10:15 Coffee-break
10:45 Discovery of Innovative Small Molecule Therapeutics
Prof Magid ABOU-GHARBIA
11:35 The Discovery of Novel Antiviral Agents
Dr. Joe VACCA
12:05 Ultra-High-Throughput Screening for Lead Discovery: Impact of Combinatorial Chemistry Compound Libraries
Dr. Stefan MUNDT
12:35 A Combinatorial Approach to Probe the Mechanism of Binding of Bivalent Ligands to GPCRs
Ms Kimberly BONGER
12:50 Lunch
14:00 Polyfunctional Zn,Mg-Organometallics for Organic Synthesis
Prof. Paul KNOCHEL
14:50 Innovation in Drug Discovery and Development Interface
Dr. Balu BALASUBRAMANIAN
15:20 From Adrenomedullin Positive Modulators to A New Type Of Mmp-2 Inhibitors
Dr. Beatriz DE PASCUAL-TERESA
15:35 Coffee-break
16:05 Surprises and Discoveries with Natural Products
Prof. Erick M. CARREIRA
16:55 Discovery of Bile Acid Resorption Inhibitors
17:25 Tetracyclic Indole Inhibitors of Hepatitis C Virus Ns5b-Polymerase
Dr. Ian STANSFIELD
17:40 Metal-Catalyzed Coupling Reactions
Prof. Gregory C. FU
19:30 City tour for participants
29/08/2007
08:30 A Tale of Two Proteases
Dr Scott A. BILLER
09:20 Positive and Negative Modulation of Family C GPCRs
Prof. Tanja WEIL
09:50 New Sugar-Derived Compounds with Anti-Septic Shock, Anti-Inflammatory and Anti-Ischemia Activity
Dr. Francesco PERI
10:05 Coffee-break
10:35 Genomic and Nongenomic Bile Acid Receptors as New Targets for Drug Discovery
Prof. Roberto PELLICCIARI
11:25 The Identification of Secretase Inhibitors for the Treatment of Alzheimer's Disease
Dr. John ELLINGBOE
11:55 Where Chemistry meets Sphingolipid Biology
12:25 Synthesis of Fosmidomycin Analogues Modified at the Three-Carbon Spacer: Towards Potent Antimalarials
Prof. Serge VAN CALENBERGH
12:40 Lunch & Poster session
BUSINESS MINI SYMPOSIUM: Discovery Chemistry Outsourcing Opportunities in Russia
14:00 Opening
Dr Gene VAISBERG
A Renewed Emphasis on Partnerships, With a Twist; The Challenge to Meet the Ever Evolving Pharma Landscape
Dr. Michael CLARK
Discovery Chemistry Sourcing in Russia. How Does it Compare to Other Regions of the World?
Dr. Richard D. CONNELL
Outsourcing Parts of the Discovery Value Chain in Russia
Dr Frederik DEROOSE
The AstraZeneca Compound Collection Enhancement Programme - Outsourcing in Russia
Dr. Garry PAIRAUDEAU
Outsourcing in Russia: the UCB Experience
Dr. Patrice TALAGA
Discovery Chemistry CROs: The Art of Playing on the Fast Changing Field
Dr Gene VAISBERG
16:05 Coffee-break
Panel discussion participants
B. BALASUBRAMANIAN (BMS, US), M. CLARK (Pfizer, US), R.D. CONNELL (Pfizer, US), F. DEROOSE (J&J Pharmaceuticals, Belgium), D. STOUT (Merck, US), W.B. KNIGHT (GSK, US), G. PAIRAUDEAU (AstraZeneca, UK), P. TALAGA (UCB, Belgium), G. VAISBERG (ChemBridge)
19:00 City tour for participants
30/08/2007
08:30 New Approaches to Biologically Validated Molecules using Chemoselective Ligation Reactions
Prof. Alessandro DONDONI
09:20 Discovery of Aclidinium Bromide, a New Long-Acting Muscarinic Antagonist for COPD Therapy
Dr. Hamish RYDER
09:50 Novel Multilabeled Oligonucleotides Containing 1-phenylethynylpyrene ara-2´-uridine-carbamate and LNA: Synthesis and Photochemical Properties
Dr. Irina ASTAKHOVA
10:05 Coffee-break
10:35 Modern Protein Chemistry
Prof. Ron RAINES
11:25 Exploiting High Throughput Screening: Case Histories
Dr Paul LEESON
11:55 Design and Synthesis of Thrombin Receptor Antagonists for the Prevention of Thrombosis
Dr William J. GREENLEE
12:45 Lunch
Free afternoon - optional tours to Hermitage, Russian Museum, 3 Cathedrals and Canals
31/08/2007
08:30 Chemical Probes of Carbohydrate Biosynthetic Pathways in Mycobacterium Tuberculosis
Prof. Laura KIESSLING
09:20 Discovery and Development of Kinase Iinhibitors by Targeting Conformational Switch Pockets. A General Platform that is Unique for Targeting ATP Pockets
Dr. Peter A. PETILLO
09:50 Synthesis of (±)-Cephalotaxine via Diallylboration-Ring Closing Metathesis-Bromocyclocarbamation Sequence
Dr Nikolai KUZNETSOV
10:05 Coffee-break
10:35 SAHA (Vorinostat), an FDA Aapproved Anticancer Compound with a Novel Mechanism of Action
Prof. Ronald BRESLOW
11:25 The Fight Against AIDS: New Avenues for Inhibiting RT, an Old Target
Prof. Maurizio BOTTA
11:55 Adventures in Medicinal Chemistry
Dr Anthony WOOD
12:25 Smiles Rearrangement and Isocyanide Chemistry
Dr. Laurence GRIMAUD
12:40 Lunch & Poster session
14:00 Transition Metal Catalyzed Reactions of Carbon-Carbon and Carbon-Heteroatom Bond Formation
Prof. Irina P. BELETSKAYA
14:50 The Power of Semi-Synthesis: The Discovery of Torisel ™
Dr. Jerauld S. SKOTNICKI
15:20 Synthesis and Characterisation of Novel Orally Available Dopamine D3 Receptor Antagonists
Dr. Sean TURNER
15:35 Coffee-break
16:05 A Systems Based Approach to Protein Kinase Research Leads to the Discovery of Tykerb, a Dual Inhibitor of EGFR and erbB2 Tyrosine Kinases
Dr. Wilson B. KNIGHT
16:35 The Inner Space of Molecules
Prof. Julius REBEK
17:25 Olefin Metathesis Catalysts for the Synthesis of Large and Small Molecules
Prof. Robert H. GRUBBS
18:15 Closing
19:00 Symposium banquet (optional)
Following the banquet, Open bridges tour(optional)
01/09/2007
08:30 Transfers to the airport
Optional tours between 9.00-18.00 / Canals, Petergof, Hermitage, Pushkin (Amber room) + Pavlovsk Palaces (tbc), Russian Museum (tbc)
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