Prof. André TARTAR (UNIVERSITY LILLE 2, Lille, France) Prof. Gérald GUILLAUMET (UNIVERSITÉ D'ORLÉANS, Orléans, France)
First Session: In Silico Selection
Session Chair:
Prof Luc MORIN-ALLORY (UNIVERSITY OF ORLEANS, Orléans, France)
09:30
Navigation in Chemistry Universe Towards Biological
Activity
Dr Peter ERTL (NOVARTIS INSTITUTE FOR BIOMEDICAL RESEARCH, Basel, Switzerland)
10:15
Structure-Based in Silico Screening: Free Tools and Applications
Dr. Bruno VILLOUTREIX (INSERM - UNIVERSITY PARIS DIDEROT, Paris, France)
Second Session: From Target Identification to Development
Session Chair:
Dr Philippe PITCHEN (FOREST RESEARCH INSTITUTE, Hauppauge, United States)
11:00
The Therapeutic Potential of Pharmacological Inhibitors of Cyclin-Dependent Kinases
Dr Laurent MEIJER (CNRS - ROSCOFF, Roscoff, France)
11:45
Targeted Small Molecule Anti-Cancer Drugs: an Asian Perspective from Discovery to Clinical
Dr. Stéphanie BLANCHARD (S*BIO, Singapore, Singapore)
12:30
Lunch and Poster Session
12:30
Career Session in parallel
From 12:30 till 16:00
Second Session: From Target Identification to Development (Fol.)
Session Chair:
Dr Luc VAN HIJFTE (JANSSEN CILAG, Val de Reuil, France)
14:30
Selective Inhibitors of MMP-12 : from Chemistry to Therapeutic Applications
Dr. Vincent DIVE (CEA, Gif-sur-Yvette, France)
15:15
Discovery of the Macrocyclic HCV Protease Inhibitor TMC435350
Dr Pierre RABOISSON (JANSSEN PHARMACEUTICAL COMPANIES, Beerse, Belgium)
16:00
Coffee Break and Poster Session
Session Chair:
Dr Solo GOLDSTEIN (INSTITUT DE RECHERCHES SERVIER, Suresnes, France)
16:30
Irreversible Serine Protease Inhibitors: Useful Tools in Drug Discovery
Prof. Koen AUGUSTYNS (UNIVERSITY OF ANTWERP, Antwerp, Belgium)
17:15
« Paul Ehrlich» Lecture: Discovery of Xarelto, a Novel, Oral Antithrombotic Agent
Dr. Susanne ROEHRIG (BAYER SCHERING PHARMA, Wuppertal, Germany)
18:00
« Paul Ehrlich» Lecture Award
Prof. Gérald GUILLAUMET (UNIVERSITÉ D'ORLÉANS, Orléans, France) Prof. André TARTAR (UNIVERSITY LILLE 2, Lille, France)
19:30
Welcome Cocktail at Hôtel Groslot (Offered by Mr. Serge Grouard, the Mayor of Orléans)
02/07/2009
Third Session: Interfacing Chembio and Medchem
Fifth Session: Imaging
Session Chair:
Dr. Grégoire PREVOST (GROUP IPSEN, Les Ulis, France)
08:30
GLP-1 Analog Taspoglutide: Design, Synthesis and Biological Activity
Dr. Jesse DONG (IPSEN, Milford, United States)
09:15
Experiences in Fragment Based Lead Discovery
Prof. Rod HUBBARD (UNIVERSITY OF YORK / VERNALIS, York, United Kingdom)
10:00
Coffee Break and Poster Session
Session Chair:
Prof. Gerard DELERIS (UNIVERSITY BORDEAUX SEGALEN, Bordeaux, France)
10:30
Using Knowledge from NBEs to Inform Drug Design
Dr. Alastair LAWSON (UCB CELLTECH, Slough, United Kingdom)
11:15
Diversity Oriented Synthesis of Natural Product Motifs
Prof. Nicolas WINSSINGER (UNIVERSITY OF STRASBOURG, Strasbourg, France)
12:00
Lunch and Poster Session
Session Chair:
Dr Jean-Philippe ROCHER (ADDEX THERAPEUTICS, Plan-les-Ouates, Switzerland)
08:30
Facilitating Drug Development with PET Imaging
Dr Yves P. AUBERSON (NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Basel, Switzerland)
09:15
Targeting G-Protein Coupled Receptors with Radiolabeled Peptides for the Molecular Imaging and Targeted Therapy of Cancer
Dr. Helmut MAECKE (UNIVERSITY HOSPITAL, Basel, Switzerland)
10:00
Coffee Break and Poster Session
Session Chair:
Dr. Jean Claude BELOEIL (CNRS UPR 4301, Orléans, France)
10:30
PET Imaging in Drug Discovery and Development of CNS Drugs
Dr. Jose Ignacio ANDRES (JOHNSON & JOHNSON PHARMACEUTICAL R & D, Toledo, Spain)
11:15
Modified Selective Integrin Ligands for Cancer Therapy, Molecular Imaging and for Improvement of Biomaterials
Dr Horst KESSLER (TECHNISCHE UNIVERSITÄT MÜNCHEN, Garching, Germany)
12:00
Lunch and Poster Session
Fourth Session: Synthesis and Lead Optimization
Sixth Session: High Throughput Screening and Lead Identification
Session Chair:
Prof. Christiane GARBAY (UNIVERSITÉ PARIS 5, Paris, France)
14:00
Discovery of Potent, Selective and Orally Bioavailable DP2 Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases
Dr. Stefano CROSIGNANI (MERCK-SERONO PHARMACEUTICAL RESEARCH INSTITUTE, Plan-les-Ouates, Switzerland)
14:45
Dynamic Combinatorial Chemistry in Chemical Biology and Drug Discovery
Prof. Jean-Marie BEAU (UNIVERSITÉ PARIS SUD 11, Orsay, France)
15:30
Development of Marine Anticancer Drugs
Dr. Andrès FRANCESCH (PHARMAMAR, Colmenar Viejo, Spain)
16:15
Coffee Break and Poster Session
Session Chair:
Ing Michel CALDERINI (MERCK, Darmstadt, Germany)
17:00
A Chemistry-Driven Approach to the Discovery of New Calcium-Sensing Receptor Ligands and Antimitotic Agents
Dr. Robert H. DODD (ICSN CNRS, Gif-Sur-Yvette, France)
17:45
Knowledge management, prospective design and chemical enablement as strategies for lead optimization: The PDE-9 inhibitor and opiate antagonist case studies.
Dr. Spiros LIRAS (PFIZER GLOBAL RESEARCH, Groton, United States)
Session Chair:
Prof. Sylvain RAULT (CERMN, Caen, France)
14:00
Generation of New Active Compounds in an Industrial-Academic Screening
Organization
Dr. Frederic AUSSEIL (INSTITUT DE RECHERCHE PIERRE FABRE, Toulouse, France)
14:45
New Strategies in Chemical Biology : Scientific and Therapeutic Outcome
Prof. Marcel HIBERT (UNIVERSITÉ DE STRASBOURG, Illkirch, France)
15:30
The Crystal Structure of the Adenosine A2A Receptor - Implications for GPCR Drug Design
Prof. Ad P. IJZERMAN (UNIVERSITY OF LEIDEN, Leiden, The Netherlands)
16:15
Coffee Break and Poster Session
Session Chair:
Dr Pascal GEORGE (SANOFI-AVENTIS R&D, Longvilliers, France)
17:00
Aptamers: Oligonucleotides that Rival Antibodies for Therapeutics and Diagnostics.
Prof. Jean-Jacques TOULME (IECB & INSERM - UNIVERSITÉ BORDEAUX II, Bordeaux, France)
17:45
Recent Developments in Structural Biology: Applying Crystallographic and NMR Approaches in Lead Finding and Optimization
Dr Vincent MIKOL (SANOFI AVENTIS, Vitry-sur-Seine, France)
18:30
End of Conference
18:45
Departure to Gala Dinner
03/07/2009
Fourth Session: Synthesis and Lead Optimization (fol.)
Session Chair:
Dr Françoise GUERITTE (INSERM - CNRS, Gif-sur-Yvette, France)
09:00
Taking up the Adme Challenge
Prof. Benoit DEPREZ (UNIVERSITY OF LILLE 2, Lille, France)
09:45
Discovery of Novel Potent, Selective and Orally Efficacious A2B Adenosine Receptor Antagonists.
Dr. Bernat VIDAL (LABORATORIOS ALMIRALL, Barcelona, Spain)
10:30
Coffee Break and Poster Session
Session Chair:
Prof Chris KRUSE (ABBOTT, Weesp, The Netherlands)
11:00
New Synthetic Methods and their Application to the Preparation of Biologically Active Molecules
Prof. Mike SHIPMAN (UNIVERSITY OF WARWICK, Coventry, United Kingdom)
11:45
« Prix Charles Mentzer »: From Heparin to New Anticoagulants with Unprecedented Pharmacological Profile
Dr. Maurice PETITOU (ENDOTIS PHARMA, Romainville, France)
12:30
« Prix Charles Mentzer » Award
Prof. Gérald GUILLAUMET (UNIVERSITÉ D'ORLÉANS, Orléans, France) Prof. André TARTAR (UNIVERSITY LILLE 2, Lille, France)
12:35
Lunch and Poster Session
Seventh Session: Biophysics Tools and ADME Tox
Session Chair:
Dr Bruno FIGADERE (UNIVERSITÉ PARIS-SUD, Chatenay-Malabry, France)
14:00
Biophysical Approaches in the Hit-to-Lead Optimisation Strategy
Dr. Jean BOUTIN (INSTITUT DE RECHERCHES SERVIER, Croissy-sur-Seine, France)
14:45
ADME-PK Optimization Strategies in Drug Discovery and Selection
Dr. Sonia POLI (ADDEX PHARMA, Plan-les-Ouates, Switzerland)
15:30
Poster Prizes
16:00
Conclusions
Prof. Gérald GUILLAUMET (UNIVERSITÉ D'ORLÉANS, Orléans, France) (EYEDPHARMA) Prof. André TARTAR (UNIVERSITY LILLE 2, Lille, France)
