|
SPICA 2012 |
Lectures confirmed to date |
| Quality by Design in API Purifications. Making the Right Things |
|
| Molecular Modeling of the Affinity Chromatography of Proteins: Status and Perspectives |
| Prof. Carlo CAVALLOTTI (POLITECNICO DI MILANO, Milano, Italy) Read more
Carlo Cavallotti received his phd in Chemical Engineering in 1999 from Politecnico di Milano. He became assistant professor in 1999 and since 2006 he is associate professor of Chemical Engineering Principles at Politecnico di Milano. In 2001 he was post doctoral associate fellow at MIT. His main research focus is theoretical chemical kinetics and molecular modeling. In particular he is interested in the modeling of biomolecular protein-protein and protein-ligand interactions, in the molecular study of chromatography processes, and in the elementary kinetics of reacting systems, both in gas phase and in solution. He is author of more than 80 papers on international peer reviewed journals and several book chapters Close window |
|
| Molecular Engineering of Multiple Weak Interactions for High Selectivity Bioseparations |
| Prof. Steven CRAMER M (RENSSELAER POLYTECHNIC INSTITUTE, Troy, United States) Read more
Steven Cramer is the William Weightman Walker Professor of Chemical and Biological Engineering at Rensselaer Polytechnic Institute, Troy, New York. He is currently conducting research on several areas related to protein-surface interactions including: rational design of high affinity and chemically selective displacers for protein and oligonucleotide purification in ion exchange and hydrophobic displacement systems, multi-scale modeling of complex chromatographic behavior, molecular modeling of selectivity and affinity in multimodal chromatographic systems, spectroscopic investigations of protein-surface interactions, chromatography on a chip, novel separation systems for proteomics, smart biopolymer affinity separation systems and development of affinity peptide based biosensors. In addition, Professor Cramer is known worldwide for his expertise in separations in general. He is the Editor-in-Chief of the International journal Separations, Science and Technology. Professor Cramer was the awarded the Alan S. Michaels Award for the Recovery of Biological Products (ACS Division of Biochemical Technology). He was also awarded Rensselaer’s School of Engineering Research Excellence Award, a Presidential Young Investigator award from the National Science Foundation, the Early Career Award from Rensselaer Polytechnic Institute as well as several teaching awards. Professor Cramer has been elected a fellow of the American Institute of Chemical Engineers and the American Institute for Medical and Biological Engineering. He has also chaired several prestigious meetings including the International HIC/RPC Bioseparations Conference, the ACS Recovery of Biological Products Meeting and the Gordon Conference on Reactive Polymers. Prof. Cramer has published 150 papers in peer-reviewed journals and has 9 patents. Importantly, he has produced 36 Ph.D. students who have gone on to leadership positions in the biotechnology industry and academia. Close window |
|
| Implementation of a Continuous Chromatography Step in The Synthesis of an API – Combining Chemistry and Chromatography to Achieve Better Economics |
| Dr Olivier DAPREMONT (AMPAC FINE CHEMICALS, Rancho Cordova, United States) Read more
Dr Dapremont earned his PhD in chemical engineering and applied chemistry from the University Pierre & Marie Curie in Paris in 1997 while working on the development of SMB technology in collaboration with Prochrom (Nancy, France). Shortly after, he moved to Chiral Technologies Europe (Strasbourg, France) to be in charge of the kilo scale separation service using a 5 cm diameter SMB unit. In 2001, he joined Aerojet Fine Chemicals, now AMPAC Fine Chemicals to be in charge of all chromatography processes. Dr Dapremont role encompasses the development of SMB separations using multiple SMB units from 4.6 mm to 1 m in diameter as well as developing continuous processes for the manufacturing of APIs. During his carrier Dr Dapremont has built several SMB units and developed many chiral separations. Dr Dapremont is co-author of several publications in scientific journals and magazines, multiple patents related to SMB technologies as well as several chapters in scientific books. Close window |
|
| New Approaches to Food Fractionation by Chromatography: Adapting High-Cost Techniques to the Production of Moderate-Value Products |
| Prof. Conan FEE (UNIVERSITY OF CANTERBURY, Christchurch, New Zealand) Read more
Professor Conan Fee graduated with a PhD in Chemical & Process Engineering at the University of Canterbury in 1989 and was a Postdoctoral Fellow at the University of Waterloo, Canada. This was followed by a joint appointment as a biochemical engineer at the Meat Industry Research Institute of NZ (MIRINZ) and as a lecturer in the School of Science and Technology at the University of Waikato. He completed a Diploma in Management (Strategic Management and Leadership) at Waikato in 1996 and moved to a full-time lectureship in the same year. He took a leading role in developing accredited engineering programmes at Waikato and eventually became Chairperson of the Department of Materials and Process Engineering there in 2003. At the beginning of 2006, he took up a Chair in Chemical Engineering at the University of Canterbury and immediately formed an alliance with researchers in chemistry and biological sciences to form the Biomolecular Interaction Centre (BIC), now one of two premiere research institutes at the University of Canterbury. He is now Co-Director of BIC, a Fellow of the Institution of Professional Engineers, New Zealand, sits on the Advisory Board of the Centre for Advanced Engineering, and in 2007 he won the Australasian Fonterra Award for Innovation in Biotechnology. Professor Fee has worked on a wide range of research and consultancy projects, from robotic, on-farm milk protein purification systems to magnetically stabilized fluidized beds, chromatographic purification and protein PEGylation. His work is now positioned at the interface between chemical engineering and biology, particularly with respect to protein interactions at surfaces. Close window |
|
| Biological Production of Peptides |
| Prof. Susanna LEONG (NANYANG TECHNOLOGICAL UNIVERSITY, Singapore, Singapore) Read more
Dr. Susanna Leong is an assistant Professor at the School of Chemical and Biomedical Engineering at Nanyang Technological University, Singapore. She received her B.Eng. and M.Phil. degrees in Chemical Engineering from the University of Manchester, and received her Ph.D. degree in Chemical Engineering from Cambridge University. Dr. Leong’s research interests are in the production and engineering of antimicrobial and biofuel molecules with the broad aim to address health and energy challenges. She has authored more than 30 papers in the areas of biomolecular and biochemical engineering. Her honors include the Danckwert-Pergamon prize awarded by the University of Cambridge. She is an Associate Editor of Chemical Engineering Science and an Editoral Board Member of IChemE Food and Bioproducts Processing (FBP) journal. Close window |
|
Oral Communications |
| Purification of Proteins from Human Blood Plasma by Multicolumn Solvent Gradient Purification |
| Mr Daniel BAUR (ETH ZÜRICH, Zurich, Switzerland) |
|
| Distributed Pore Surface Model |
| Ing Niklas BORG (LUND UNIVERSITY, Lund, Sweden) |
|
| Towards Optimally Sized Centrifugal Partition Chromatography Columns - Process Design Methodology and Applications |
| Mr Sebastien CHOLLET (GEPEA LABORATORY, Saint-Nazaire, France) |
|
| A Model Based Approach to Reducing the Analytical Burden of High Throughput Screening |
| Dr Marcus DEGERMAN (LUND UNIVERSITY, Lund, Sweden) |
|
| Liquid-Liquid Extraction of Biomolecules - Process Development and Integration into Downstream Processing |
| Mr Jan Kristof EGGERSGLUESS (CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal, Germany) |
|
| Characterization of Adsorption in SFC: an Evaluation of Methods Used in LC |
| Prof. Torgny FORNSTEDT (KARLSTAD UNIVERSITY, Karlstad, Sweden) |
|
| New Trend in Material Development for Peptide Purification |
| Dr Nicola FORRER (ZEOCHEM, Uetikon am See, Switzerland) |
|
| Preparative Chiral Chromatography: What Can Go Wrong and How to Solve it |
| Dr Pilar FRANCO (CHIRAL TECHNOLOGIES, INC, Illkirch, France) |
|
| From Racemate to Single Enantiomer with 100% Yield by Process Integration of SMB and Enzymatic Racemization |
| Mr Markus FUEREDER (ETH ZURICH, Basel, Switzerland) |
|
| Modeling Protein Adsorption Equilibria on Ion-Exchange Resins |
| Dr Bertrand GUELAT (NOVARTIS PHARMA AG, Basel, Switzerland) |
|
| Quality by Design with Rigorous Process Modeling as Platform Technology of the Future |
| Mr Christoph HELLING (CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany) |
|
| Experimental Study on a Binary Chromatographic System Subject to a Mixed Competitive-Cooperative Adsorption Isotherm |
| Mr Simon JERMANN (ETH ZÜRICH, Zurich, Switzerland) |
|
| Separation of Bionanoparticles and Biological Superstructures |
| Prof. Alois JUNGBAUER (UNIV AGRICULTURAL SCIENCES, Vienna, Austria) |
|
| Integrated Chromatographic Processes for the Production of Pure Enantiomers |
| Prof. Malte KASPEREIT (FRIEDRICH-ALEXANDER UNIVERSITY ERLANGEN-NUREMBERG, Erlangen, Germany) |
|
| Model Mismatch Resolution and Optimization for Simulated Moving Bed and Continuous Chromatographic Processes |
| Prof. Yoshiaki KAWAJIRI (GEORGIA INSTITUTE OF TECHNOLOGY, Atlanta, United States) |
|
| A Non-Conventional Application of Simulated Moving Bed Technology: Purification of a Complex Mixture |
| Ms Kiara KOCHENDOERFER (BASF SE, Ludwigshafen, Germany) |
|
| Model Based Design and Integration of Crystallization Processes of Natural Products in Down Stream Processing |
| Mr Iraj KOUDOUS (INSITUT FÜR THERMISCHE VERFAHRENS- UND PROZESSTECHNIK, Clausthal-Zellerfeld, Germany) |
|
| Continuous Synthesis and Purification Through Direct Combination of a Flow Reactor and Simulated Moving Bed Chromatography |
| Dr Ju Weon LEE (MAX-PLANCK-INSTITUTE FOR DYNAMICS OF COMPLEX TECHINCAL SYSTEMS, Magdeburg, Germany) |
|
| Nanofiltration of Peptides in Acetonitrile/Water Mixtures: Process Development |
| Ms Patrizia MARCHETTI (LONZA, Visp, Switzerland) |
|
| Continuous Purification of Single-Chain Antibody Fragments by Simulated Moving Bed Chromatography |
| Mr Carlos Andres MARTINEZ CRISTANCHO (MAX-PLANCK-INSTITUT MAGDEBURG, Magdeburg, Germany) |
|
| Design Of Tailor-Made Stationary And Mobile Phase In Liquid-Liquid Chromatography |
| Prof. Mirjana MINCEVA (TECHNICAL UNIVERSITY OF MUNICH, Freising, Germany) |
|
| Relay SMB: A Simple and Efficient Way of Implementing Simulated Moving-Bed Chromatography |
| Prof. José Paulo MOTA (UNIVERSIDADE NOVA DE LISBOA, Caparica, Portugal) |
|
| Enabling High Purities and Yields in Therapeutic Peptide Purification by Using Continuous Chromatography (MCSGP) |
| Dr Thomas MÜLLER-SPÄTH (CHROMACON AG, Zurich, Switzerland) |
|
| Efficient API Purification or How Combining OSN and Chromatography Increases Your Process Yields! |
| Dr Muriel NASSO (EVONIK, Wembley, United Kingdom) |
|
| Modeling of Protein Aggregation in Preparative Chromatography |
| Prof. Bernt NILSSON (LUND UNIVERSITY, Lund, Sweden) |
|
| Peptidomimetic Affinity Ligands (PALs) - A Powerful Approach to Improving DSP Performance |
|
| Shifting the Scale-up Limits of Disposable Downstream Processing |
|
| Optimization of Simulated Moving Bed Processes for Multicomponent Chiral Separations |
| Dr António E. RIBEIRO (POLYTECHNIC INSTITUTE OF BRAGANÇA, Bragança, Portugal) |
|
| Supercritical Fluids as the Desorbent for Simulated Moving Bed? Application to the Concentration of Triterpenoids from Taiwanofugus Camphorate |
| Ms Liang RU CHIEN (I SHOU UNIVERSITY, Kaohsiung City, Taiwan) |
|
| Chromatographic Process Options for Reduced Purities |
| Prof. Tuomo SAINIO (LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland) |
|
| Study of Hydrodynamics in Chromatographic Columns by Computed X-Ray Tomography and its Evaluation by CFD Simulations |
| Ms Irma SCHMIDT (UNIVERSITY ERLANGEN-NUREMBERG, Erlangen, Germany) |
|
| Scalable Technology for the Extraction of Pharmaceuticals (STEP): Progress on Developing Versatile Small Footprint Technology for Continuous Processing at the Lab Scale up to 1 Kg/Day |
| Prof. Ian SUTHERLAND (BRUNEL INSTITUTE FOR BIOENGINEERING, Uxbridge, United Kingdom) |
| Dr Svetlana IGNATOVA (BRUNEL UNIVERSITY, Uxbridge, United Kingdom) |
|
| A Reaction-Separation Integrated Process for the High-Yield Synthesis of Rare Sugars |
| Ms Nina WAGNER (ETH ZURICH D-BSSE, Basel, Switzerland) |
|
| Integration of Hydrophobic Interaction- and Ion Exchange Chromatography |
| Mr Tim WELLSANDT (INSITUT FÜR THERMISCHE VERFAHRENS- UND PROZESSTECHNIK, Clausthal-Zellerfeld, Germany) |
|
| A New Disposable Technology for Chromatographic Purification of Biopharmaceuticals |
| Dr David YAVORSKY (MERCK-MILLIPORE, Bedford, United States) |
|
Workshops |
| From Development to Commercial Scale: Rules to Scale up, QbD, Regulatory, Process Validation |
| Dr Alessandro BUTTE (ETH ZURICH, Zurich, Switzerland) Read more
Alessandro Butté received his Ph.D. in Chemical Engineering in 2000 from ETH Zurich. After a two-year post-doc at the Georgia Institute of Technology, he join the group of Prof. Morbidelli at ETH Zurich and completed his habilitation in 2008. During this period, his research activities focused on polymer engineering, production of nano-materials for protein purification (monoliths by reactive-gelation) and chromatography purifications of peptides, proteins and Mabs. In 2008, he joined Lonza as responsible for downstream activities in the sectors small molecules and peptides. He is currently leading the share best practice team for chromatographic and membrane separations and he is involved in the pilot program to introduce Quality by Design into R&D. He is author of more than 30 papers on international peer reviewed journals and several book chapters. Close window |
|
| Process Design for Purification of Biomolecules |
| Prof. Alois JUNGBAUER (UNIV AGRICULTURAL SCIENCES, Vienna, Austria) |
|
| Multicolumn Processes: from Historical SMB to the Latest Advances in the Purification of Biomolecules |
| Prof. Arvind RAJENDRAN (UNIVERSITY OF ALBERTA, Edmonton, AB, Canada) |
|
| Preparative HPLC : Phase Screening, Method Optimization, Process Development. Troubleshooting a Preparative Chromatographic Device
|
| Dr Michael SCHULTE (MERCK, Darmstadt, Germany) |
|
| Process Design for Purification of Small Molecules
|
| Prof. Jochen STRUBE (CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany) |
|
| Solving a Purification Process: Choice of the Appropriate Process (Batch vs Continuous, Low Pressure vs High Pressure, Liquid vs SFC, Centrifugal Partition Chromatography vs Countercurrent Chromatography) |
| Dr Eric VALERY (NOVASEP, Pompey, France) |
|
<Previous page |