SPICA 2012 30/09/2012
13:00 Registration
Workshop 1 Workshop 2 Workshop 3
14:00 Preparative HPLC : Phase Screening, Method Optimization, Process Development. Troubleshooting a Preparative Chromatographic Device
Dr Michael SCHULTE
14:00 Multicolumn Processes: from Historical SMB to the Latest Advances in the Purification of Biomolecules
Prof. Arvind RAJENDRAN
15:30 Coffee Break
Workshop 4 Workshop 5 Workshop 6
16:00 Solving a Purification Process: Choice of the Appropriate Process (Batch vs Continuous, Low Pressure vs High Pressure, Liquid vs SFC, Centrifugal Partition Chromatography vs Countercurrent Chromatography)
Dr Eric VALERY
16:00 Process Design for Purification of Small Molecules
Prof. Jochen STRUBE
16:00 Process Design for Purification of Biomolecules
Prof. Alois JUNGBAUER
18:00 Welcome reception
01/10/2012
09:00 Welcome
Session 1: Quality by Design
Session Chair
Prof. Massimo MORBIDELLI
09:20 Quality by Design in API Purifications. Making the Right Things
Dr Alessandro BUTTE
10:00 Quality by Design with Rigorous Process Modeling as Platform Technology of the Future
Mr Christoph HELLING
10:20 A Model Based Approach to Reducing the Analytical Burden of High Throughput Screening
Dr Marcus DEGERMAN
10:40 Characterization of Adsorption in SFC: an Evaluation of Methods Used in LC
Prof. Torgny FORNSTEDT
11:00 Coffee Break
Session 2: Multicolumn Chromatography
Session Chair
Dr Eric FRANCOTTE
11:30 Experimental Study on a Binary Chromatographic System Subject to a Mixed Competitive-Cooperative Adsorption Isotherm
Mr Simon JERMANN
11:50 Relay SMB: A Simple and Efficient Way of Implementing Simulated Moving-Bed Chromatography
Prof. José Paulo MOTA
12:10 Model Mismatch Resolution and Optimization for Simulated Moving Bed and Continuous Chromatographic Processes
Prof. Yoshiaki KAWAJIRI
12:30 Lunch, Vendor Seminar (Novasep, Waters, Phenomenex, Knauer)
Session 3: Innovative Production Technologies
Session Chair
Prof. Andreas SEIDEL-MORGENSTERN (MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany) Prof. Tuomo SAINIO (LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland)
14:00 Biological Production of Peptides
Prof. Susanna LEONG
14:40 Nanofiltration of Peptides in Acetonitrile/Water Mixtures: Process Development
Ms Patrizia MARCHETTI
15:00 Efficient API Purification or How Combining OSN and Chromatography Increases Your Process Yields!
Dr Muriel NASSO
15:20 Separation of Bionanoparticles and Biological Superstructures
Prof. Alois JUNGBAUER
15:40 Coffee Break
Session 4: Fundamentals
Session Chair
Prof. Alois JUNGBAUER
16:10 Molecular Engineering of Multiple Weak Interactions for High Selectivity Bioseparations
Prof. Steven CRAMER M
16:50 Modeling of Protein Aggregation in Preparative Chromatography
Prof. Bernt NILSSON
17:10 Modeling Protein Adsorption Equilibria on Ion-Exchange Resins
Dr Bertrand GUELAT
17:30 Distributed Pore Surface Model
Ing Niklas BORG
17:50 Study of Hydrodynamics in Chromatographic Columns by Computed X-Ray Tomography and its Evaluation by CFD Simulations
Ms Irma SCHMIDT
18:10 Poster Session #1
02/10/2012
07:00 Young Scientist Breakfast
Session 5: Green Technology - Complex Continuous Resolution
Session Chair
Prof. Arvind RAJENDRAN (UNIVERSITY OF ALBERTA, Edmonton, AB, Canada) Dr Svetlana IGNATOVA (BRUNEL UNIVERSITY, Uxbridge, United Kingdom)
08:50 Preparative Chiral Chromatography: What Can Go Wrong and How to Solve it
Dr Pilar FRANCO
09:10 Supercritical Fluids as the Desorbent for Simulated Moving Bed? Application to the Concentration of Triterpenoids from Taiwanofugus Camphorate
Ms Liang RU CHIEN
09:30 Optimization of Simulated Moving Bed Processes for Multicomponent Chiral Separations
Dr António E. RIBEIRO
09:50 A Non-Conventional Application of Simulated Moving Bed Technology: Purification of a Complex Mixture
Ms Kiara KOCHENDOERFER
10:10 Coffee Break
Session 6: Partitioning and Extraction
Session Chair
Prof. Joachim KINKEL
10:40 Liquid-Liquid Extraction of Biomolecules - Process Development and Integration into Downstream Processing
Mr Jan Kristof EGGERSGLUESS
11:00 Design Of Tailor-Made Stationary And Mobile Phase In Liquid-Liquid Chromatography
Prof. Mirjana MINCEVA
11:20 Towards Optimally Sized Centrifugal Partition Chromatography Columns - Process Design Methodology and Applications
Mr Sebastien CHOLLET
11:40 Scalable Technology for the Extraction of Pharmaceuticals (STEP): Progress on Developing Versatile Small Footprint Technology for Continuous Processing at the Lab Scale up to 1 Kg/Day
Prof. Ian SUTHERLAND (BRUNEL INSTITUTE FOR BIOENGINEERING, Uxbridge, United Kingdom) Dr Svetlana IGNATOVA (BRUNEL UNIVERSITY, Uxbridge, United Kingdom)
12:00 Lunch, Vendor Seminar (Kromasil, Merck Millipore, PIC Solution and Chiral Technologies)
Session 7: Process Integration 1 - Isomeric Separation
Session Chair
Dr Shalini ANDERSSON (ASTRAZENECA, Mölndal, Sweden) Prof. Mirjana MINCEVA (TECHNICAL UNIVERSITY OF MUNICH, Freising, Germany)
13:30 Implementation of a Continuous Chromatography Step in The Synthesis of an API – Combining Chemistry and Chromatography to Achieve Better Economics
Dr Olivier DAPREMONT
14:10 Continuous Synthesis and Purification Through Direct Combination of a Flow Reactor and Simulated Moving Bed Chromatography
Dr Ju Weon LEE
14:30 Integrated Chromatographic Processes for the Production of Pure Enantiomers
Prof. Malte KASPEREIT
14:50 From Racemate to Single Enantiomer with 100% Yield by Process Integration of SMB and Enzymatic Racemization
Mr Markus FUEREDER
15:10 Coffee Break sponsored by AMPAC Fine Chemicals
Session 8: Process Integration 2 - Food and Products
Session Chair
Dr Eric VALERY (NOVASEP, Pompey, France) Prof. Malte KASPEREIT (FRIEDRICH-ALEXANDER UNIVERSITY ERLANGEN-NUREMBERG, Erlangen, Germany)
15:40 New Approaches to Food Fractionation by Chromatography: Adapting High-Cost Techniques to the Production of Moderate-Value Products
Prof. Conan FEE
16:20 A Reaction-Separation Integrated Process for the High-Yield Synthesis of Rare Sugars
Ms Nina WAGNER
16:40 Chromatographic Process Options for Reduced Purities
Prof. Tuomo SAINIO
17:00 Model Based Design and Integration of Crystallization Processes of Natural Products in Down Stream Processing
Mr Iraj KOUDOUS
17:20 Special Symposium - Rountable Discussion: Process Integration and Intensification
Dr Olivier DAPREMONT (AMPAC FINE CHEMICALS, Rancho Cordova, United States) Dr Eric VALERY (NOVASEP, Pompey, France) Dr Shalini ANDERSSON (ASTRAZENECA, Mölndal, Sweden)
18:00 Poster Session 2
20:00 Gala Dinner
03/10/2012
Session 9: SMB and Novel Chromatography Approaches
Session Chair
Prof. José Paulo MOTA
08:50 Enabling High Purities and Yields in Therapeutic Peptide Purification by Using Continuous Chromatography (MCSGP)
Dr Thomas MÜLLER-SPÄTH
09:10 Continuous Purification of Single-Chain Antibody Fragments by Simulated Moving Bed Chromatography
Mr Carlos Andres MARTINEZ CRISTANCHO
09:30 Integration of Hydrophobic Interaction- and Ion Exchange Chromatography
Mr Tim WELLSANDT
09:50 Purification of Proteins from Human Blood Plasma by Multicolumn Solvent Gradient Purification
Mr Daniel BAUR
10:10 Poster Prize
10:30 Coffee Break
Session 10: Affinity Ligands and Biopharmaceuticals
Session Chair
Prof. Jochen STRUBE
11:00 Molecular Modeling of the Affinity Chromatography of Proteins: Status and Perspectives
Prof. Carlo CAVALLOTTI
11:40 Peptidomimetic Affinity Ligands (PALs) - A Powerful Approach to Improving DSP Performance
Dr Matthias PASCHKE
12:00 New Trend in Material Development for Peptide Purification
Dr Nicola FORRER
12:20 A New Disposable Technology for Chromatographic Purification of Biopharmaceuticals
Dr David YAVORSKY
12:40 Shifting the Scale-up Limits of Disposable Downstream Processing
Mr. Marcel RAEDTS
13:00 Closing Remarks
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